Abstract
A new method for the aromatization of ring A in androsta-1,4-diene-3,17-dione, available from sterols by means of the microbiological degradation of the side chain, was developed. The method consists of the reduction of androsta-1,4-diene-3,17-dione to the corresponding dienediol followed by double C,O-deprotonation of ring A, accompanied by expulsion of the 19-methyl group and formation of estradiol in a high yield.
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Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 599–601, March, 1999.
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Vasiljeva, L.L., Demin, P.M., Kochev, D.M. et al. New synthesis of estradiol from androsta-1,4-diene-3,17-dione. Russ Chem Bull 48, 593–595 (1999). https://doi.org/10.1007/BF02496187
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DOI: https://doi.org/10.1007/BF02496187