Russian Chemical Bulletin

, Volume 46, Issue 7, pp 1303–1305 | Cite as

[3+3] Cyclocondensation of 1-alkyl-substituted 3,4-dihydroisoquinolines with 2-aminomethylenecycloalkane-1,3-diones or aminomethylene malonates: A novel annelation reaction in the series of cyclic Schiff's bases

  • O. V. Gulyakevich
  • A. L. Mikhal'chuk
  • A. A. Akhrem
Asymmetric Nitrogen
  • 35 Downloads

Abstract

A new approach to the construction of polycyclic skeletons of fused azines with nitrogen at the bridgehead based on a novel reaction of cyclic Schiff's bases (1-alkyl-substituted 3,4-dihydroisoquinolines) with α-aminomethylenecarbonyl compounds (2-aminomethylene-cyclohexane-1,3-diones or aminomethylenemalonic ester) was developed.

Key words

cyclic Schiff's bases azomethines 1-alkyl-3,4-dihydroisoquinolines enamines aminoenones β-aminoacrylates 2-aminomethylenecyclohexane-1,3-diones aminomethylene malonates benzo[a]quinolizines dibenzo[a,f]quinolizinium chlorides 8-aza-d-homogonanium chlorides 8-azasteroids [3+3]cyclocondensation annelation 

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Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • O. V. Gulyakevich
    • 1
  • A. L. Mikhal'chuk
    • 1
  • A. A. Akhrem
    • 1
  1. 1.Institute of Bioorganic ChemistryAcademy of Sciences of BelarusMinskBelarus

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