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Reactions of ethyl 3-(diethoxyphosphoryl)-3,3-difluoropyruvate with some nucleophilic reagents

  • Organic Chemistry
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Russian Chemical Bulletin Aims and scope

Abstract

Reactions of ethyl 3-(diethoxyphosphoryl)-3,3-difluoro-2-oxopropionate with a number of nucleophilic reagents were studied. New procedures were developed for the synthesis of difluoromethylphosphonate-substituted nitrogen heterocycles. The ketoester under study is much less reactive in C-hydroxyalkylation of aromatic amines than methyl 3,3,3-trifluoropyruvate.

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Authors and Affiliations

  1. A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 ul. Vavilova, 117813, Moscow, Russian Federation

    P. V. Pasternak, A. S. Golubev, A. S. Peregudov & N. D. Chkanikov

Authors
  1. P. V. Pasternak
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  2. A. S. Golubev
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  3. A. S. Peregudov
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  4. N. D. Chkanikov
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Published inIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1258–1260, July, 2000.

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Pasternak, P.V., Golubev, A.S., Peregudov, A.S. et al. Reactions of ethyl 3-(diethoxyphosphoryl)-3,3-difluoropyruvate with some nucleophilic reagents. Russ Chem Bull 49, 1255–1256 (2000). https://doi.org/10.1007/BF02495770

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  • DOI: https://doi.org/10.1007/BF02495770

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