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Russian Chemical Bulletin

, Volume 47, Issue 8, pp 1565–1570 | Cite as

Oxidation of nitrogen-containing heterocycles using biocatalysts

  • T. I. Davidenko
Organic Chemistry

Abstract

A method for stereospecific hydroxylation of 1,2-dihydro-3H-1,4-benzodiazepin-2-ones using free and immobilized cells of actinomycetes as biocatalysts was developed. The hydroxylation under the action of yeast results in the formation of racemates. Actinomyces do not hydroxylate quinazolinones, quinoxalinones, and tetrahydro-1,5-benzodiazepin-2-ones; derivatives of 1,2,3,4-tetrahydro-1,5-benzodiazocin-2-ones are transformed into 2-[N-(3-acetylaminopropionyl)amino]benzophenones.

Key words

1,4-benzodiazepin-2-ones quinazolinones quinoxalinones 1,5-benzodiazepin-2-ones 1,5-benzodiazocin-2-ones hydroxylation actinomycete and yeast cells immobilization in carrageenan 

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Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • T. I. Davidenko
    • 1
  1. 1.A. V. Bogatsky Physico-Chemical InstituteNational Academy of Sciences of UkraineOdessaUkraine

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