Abstract
6-Substituted 7-halo-3,3-bis(trifluoromethyl)-2-azabicyclo[2.2.1]heptanes were synthesized by the addition of water, alcohols, and acetic acid to 3-halo-7,7-bis(trifluoromethyl)-1-azatricyclo[2.2.1.02,6]heptanes in the presence of H2SO4. 5,6-Disubstituted 3,3-bis(trifluoromethyl)-2-azabicyclo[2.2.1]heptanes were prepared by oxymercuration of 3,3-bis(trifluoromethyl)-2-azabicyclo[2.2.1]hept-5-ene.
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V. M. Nagaev, G. A. Sokolsky, S. S. Khokhlov, and A. F. Yeleyev,Izv. Akad. Nauk, Ser. Khim., 1997, 1649 [Russ. Chem. Bull., 1997,46, 1572 (Engl. Transl.)].
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For Part 1, see Ref. 1
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 133–136, January, 1998.
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Nagaev, V.M., Sokolsky, G.A., Khokhlov, S.S. et al. Bis(trifluoromethyl)-containing 1-azatricycloheptanes. Russ Chem Bull 47, 134–138 (1998). https://doi.org/10.1007/BF02495520
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DOI: https://doi.org/10.1007/BF02495520