Abstract
Reactions of α-(1-benzotriazolyl)ethylferrocene (1) with 1,2,4-triazole, imidazole, benzimidazole, and edenine have been studied in the MeOH−HCl, MeOH, and AcOH systems. Compound 1 is a novel ferrocenylalkylating reagent which, unlike α-hydroxyalkylferrocenes, is capable of alkylating imidazole, benzimidazole (even in the absence of an acid catalyst), and adenine (regioselectively at the N(3) position). The antitumor activity discovered for ferrocenylalkylazoles of the type 1 may be attributed to the ability of such compounds to ferrocenylalkylate nucleic bases.
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Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 172–174, January, 1997.
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Gumenyuk, V.V., Zhilina, Z.V., Nekrasov, Y.S. et al. A novel ferrocenylalkylating reagent. Ferrocenylalkylation of imidazole and its derivatives. Russ Chem Bull 46, 168–170 (1997). https://doi.org/10.1007/BF02495368
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DOI: https://doi.org/10.1007/BF02495368