Abstract
Treatment of 2,2-dimethyl-6-trifluoro(trichloro)methyl-2,3-dihydro-4-pyrones with ammonia gives 4-amino-1,1,1-trifluoro(trichloro)-6-methylhepta-3,5-dien-2-ones. Under similar conditions 1,1,1-trifluoro-2-hydroxy-6-methylhepta-2,5-dien-4-one and 6-chloro-1, 1,1-trifluoro-2-hydroxy-6-methylhept-2-en-4-one cyclize into 2,2-dimethyl-6-trifluoromethyl-2,3-dihydro-4-pyridone.
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References
V. Ya. Sosnovskikh and I. S. Ovsyannikov,Zh. Org. Khim., 1993,29, 259 [J. Org. Chem., 1993,29 (Engl. Transl.)].
L. B. Barkley and R. Levine,J. Am. Chem. Soc., 1951,73, 4625.
V. Ya. Sosnovskikh and I. S. Ovsyannikov,Zh. Org. Khim., 1993,29, 89 [J. Org. Chem., 1993,29 (Engl. Transl.)].
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Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2263–2265, December, 1997.
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Sosnovskikh, V.Y. A simple synthesis of 4-amino-6-methyl-1,1,1-trifluoro(trichloro)hepta-3,5-dien-2-ones and 2,2-dimethyl-6-trifluoromethyl-2,3-dihydro-4-pyridone. Russ Chem Bull 46, 2145–2146 (1997). https://doi.org/10.1007/BF02495272
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DOI: https://doi.org/10.1007/BF02495272