Synthesis of 5-hydroxy-N-(2-vinyloxyalkyl)indoles from dicarbonyl compounds and vinyloxyalkylamines
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N-(Vinyloxyalkyl)enaminoketones were obtained by the condensation of vinyloxyalkylamines with acetylacetone or ethyl acetoacetate. Their subsequent reactions with 1,4-benzoquinone produce the corresponding 5-hydroxy-2-methyl-N-(2-vinyloxyalkyl)indoles in 17–43% yields. The structures of the compounds obtained were confirmed by IR and1H NMR spectroscopy.
Key words3-acetyl-5-hydroxy-2-methyl-N-(2-vinyloxyalkyl)indoles ethyl 5-hydroxy-2-methyl-N-(2-vinyloxyalkyl)indole-3-carboxylates vinyloxyalkylamines enaminoketones
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