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Synthesis and studies of organic nitrates of the heterofunctional series

1. Synthesis and structure ofN-nicotinoyltris(hydroxymethyl)aminomethane trinitrate hydronitrate

  • Organic Chemistry
  • Published:
Russian Chemical Bulletin Aims and scope

Abstract

N-Nicotinoyltris(hydroxymethy)aminomethane trinitrate hydronitrate, an analog ofN-nicotinoylethanolamine nitrate (the active principle of the antianginal drug nicorandil), was prepared byO-nitration of the corresponding triol with concentrated HNO3. The structure of the reaction product was established by X-ray structural analysis.

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Authors and Affiliations

  1. Institute of Chemical Physics in Chernogolovka, Russian Academy of Sciences, 142432, Chernogolovka, Moscow Region, Russian Federation

    A. M. Korolev, L. T. Eremenko & L. V. Meshikhina

  2. N. S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 31 Leninsky prosp., 117907, Moscow, Russian Federation

    I. L. Eremenko & S. E. Nefedov

Authors
  1. A. M. Korolev
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  2. L. T. Eremenko
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  3. L. V. Meshikhina
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  4. I. L. Eremenko
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  5. S. E. Nefedov
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Additional information

Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2224–2227, December, 1997.

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Korolev, A.M., Eremenko, L.T., Meshikhina, L.V. et al. Synthesis and studies of organic nitrates of the heterofunctional series. Russ Chem Bull 46, 2110–2112 (1997). https://doi.org/10.1007/BF02495262

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  • DOI: https://doi.org/10.1007/BF02495262

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