Russian Chemical Bulletin

, 49:1624 | Cite as

Reaction of guaianolide achillin with chlorine in methanol

  • O. V. Alebastrov
  • V. A. Raldugin
  • M. M. Shakirov
  • I. Yu. Bagryanskaya
  • Yu. V. Gatilov
  • A. T. Kulyjasov
  • S. M. Adekenov
  • G. A. Tolstikov
Chemistry of Natural Compounds and Bioorganic Chemistry


The reaction of sesquiterpene lactone achillin with chlorine in methanol afforded four products,viz., two monochlorides and two dichlorides. One of these monochlorides is an intermediate in the formation of both dichlorides. The structures of the reaction products were established by two-dimensional NMR spectroscopy. The structure of one of the products was also established by X-ray diffraction analysis.

Key Words

sesquiterpenoid guaianolides achillin chlorination two-dimensional NMR spectroscopy X-ray diffraction analysis 


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Copyright information

© Kluwer Academic/Plenum Publishers 2000

Authors and Affiliations

  • O. V. Alebastrov
    • 1
  • V. A. Raldugin
    • 2
  • M. M. Shakirov
    • 2
  • I. Yu. Bagryanskaya
    • 2
  • Yu. V. Gatilov
    • 2
  • A. T. Kulyjasov
    • 1
  • S. M. Adekenov
    • 1
  • G. A. Tolstikov
    • 2
  1. 1.Institute of PhytochemistryMinistry of Sciences and Higher Education of Kazakhstan RepublicKaragandaKazakhstan Republic
  2. 2.N. N Vorozhtsov Novosibirsk Institute of Organic ChemistrySiberian Branch of the Russian Academy of SciencesNovosibirskRussian Federation

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