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Synthesis and biological activity of some 1,3,2-diheteraphosphorinanes and their acyclic analogs

  • Organic Chemistry
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Abstract

Methods were developed for the synthesis of 2-butylthio-2-oxo-1,3,2-oxazaphosphorinane, 2-butylthio-2-thioxo-1,3,2-dioxaphosphorinane, and 2-butylthio-2-thioxo-1,3,2-diazaphosphorinane, as well as of acyclicS-butylO-ethyl (diethylamido)phosphorothioates and-dithioates andS-butyl bis(diethylamido)phosphorodithioate. These compounds can serve as models of possible metabolites of cyclic compounds. Based on the data obtained in studies of the antiesterase activity of the resulting compounds and their synergistic activity in mixtures with permethrine, a possible mechanism ofin vitro andin vivo biological action of diheteraphosphorinanes was proposed.

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Authors and Affiliations

  1. A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 ul. Vavilova, 117813, Moscow, Russian Federation

    A. E. Shipov, O. I. Artyushin, G. K. Genkina & T. A. Mastryukova

  2. V. I. Lenin Moscow State Pedagogical University, 1 ul. M. Pirogovskaya, 119435, Moscow, Russian Federation

    A. V. Khrunin

  3. Scientific Research Institute of Disinfectology, 18 Nauchnyi pr., 117246, Moscow, Russian Federation

    O. Yu. Eremina, E. I. Bakanova & S. A. Roslavtseva

Authors
  1. A. E. Shipov
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  2. O. I. Artyushin
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  3. G. K. Genkina
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  4. A. V. Khrunin
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  5. O. Yu. Eremina
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  6. E. I. Bakanova
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  7. S. A. Roslavtseva
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  8. T. A. Mastryukova
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Additional information

Published inIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 9, pp. 1604–1608, September, 2000.

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Shipov, A.E., Artyushin, O.I., Genkina, G.K. et al. Synthesis and biological activity of some 1,3,2-diheteraphosphorinanes and their acyclic analogs. Russ Chem Bull 49, 1593–1597 (2000). https://doi.org/10.1007/BF02495165

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  • DOI: https://doi.org/10.1007/BF02495165

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