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Reactions of regioisomeric 3,3-dimethyl- and 2,2-dimethyl-6-trifluoromethyl-2,3-dihydro-4-pyrones with N-nucleophiles

  • Organic Chemistry
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Russian Chemical Bulletin Aims and scope

Abstract

Reactions of 2,2-dimethyl-6-trifluoromethyl-2,3-dihydro-4-pyrone with ethylenediamine, hydrazine, or hydroxylamine yield 5-methyl-7-trifluoromethyl-2,3-dihydro-1H-1,4-diazepine, 3(5)-(2-hydroxy-2-methylpropyl)-5(3)-trifluoromethylpyrazole, and 5-hydroxy-3-(2-hydroxy-2-methylpropyl)-5-triflouromethyl-Δ2, respectively. The same compounds were obtained from 2-amino-1,1,1-trifluoro-6-hydroxy-6-methylhept-2(Z)-en-4-one and 2-hydroxy-6, 6-dimethyl-2-trifluoromethyltetrahydro-4-pyrone.

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Authors and Affiliations

  1. A. M. Gorky Ural State University, 51 prosp. Lenina, 620083, Ekaterinburg, Russian Federation

    V. Ya. Sosnovskikh & M. Yu. Mel'nikov

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  1. V. Ya. Sosnovskikh
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  2. M. Yu. Mel'nikov
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Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 983–986, May, 1999.

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Sosnovskikh, V.Y., Mel'nikov, M.Y. Reactions of regioisomeric 3,3-dimethyl- and 2,2-dimethyl-6-trifluoromethyl-2,3-dihydro-4-pyrones with N-nucleophiles. Russ Chem Bull 48, 975–978 (1999). https://doi.org/10.1007/BF02494648

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  • DOI: https://doi.org/10.1007/BF02494648

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