Summary
The synthesis of the complex [Ru(cyclam)Cl2]Cl (cyclam=1,4,8,11-tetraazacyclotetradecane) has been monitored by reversed-phase high-performance liquid chromatography. The analytical results obtained during the reaction have shown that it is feasible to identify and isolate the two isomerscis- andtrans- [Ru(cyclam)-Cl2]Cl. The use of an octadecylsiloxy preparative column enabled the separation and purification of these two isomers and the compounds have been obtained in high purity. The use of reversed-phase high-performance liquid chromatography has afforded complete analytical control of the syntheses of saturated nitrogendonor macrocyclic complexes of ruthenium, enabling identification of thecis andtrans isomers of the complex [Ru(cyclam)Cl2]Cl.
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References
P. C. Ford, Coordination Chem. Rev.5, 75 (1970).
S. S. Izied, Inorg. Chem.19, 911 (1980).
S. S. Izied, H. Taube, Inorg. Chem.15, 3070, (1976).
S. S. Izied, Metal Ions in Biological Systems, Marcel Decker, New York, USA, 1991.
I. S. Moreira, J. Sun, M. O. K. Cho, J. F. Wishart, S. S. Izied, J. Am. Chem. Soc.116, 8396 (1994).
J. R. Winkler, H. B. Gray, Chem. Rev.92, 369 (1992).
S. S. Izied, I. S. Moreira, M. Y. Ogawa, A. Vassilian, B. Arbor, J. Sun, J. Photochem. Photobiol. A Chem.82, 203 (1994).
R. S. Silva, E. Tfouni, Inorg. Chem.31, 3313 (1992).
C. K. Poon, C. M. Che, J. Chem. Soc. Dalton 756 (1980).
P. K. Chan, D. A. Izabirye, C. K. Poon, Inorg. Chem.14, 2579 (1975).
D. D. Walker, H. Taube, Inorg. Chem.20, 2828 (1981).
P. R. James, R. S. Mcmillan, Inorg. Nucl. Chem. Lett.11, 837 (1975).
S. Tachiyashiki, H. Ikezada, K. Mizumachi, Inorg. Chem.33, 623 (1994).
M. Y. Khuhawar, Z. P. Memon, S. N. Lanjwani, Chromatographia41, 236 (1995).
H. E. Toma, D. O. Silva, Chromatographia32, 546 (1991).
I. S. Moreira, M. O. Santiago, Chromatographia43, 322 (1996).
H. Veening, B. R. Willeford, Rev. Inorg. Chem.3, 281 (1979).
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Diógenes, I.C.N., de Sousa, J.R. & Moreira, I.S. Monitoring of the synthesis ofcis andtrans ruthenium macrocyclic complexes by reversed-phase high-performance liquid chromatography. Chromatographia 50, 105–108 (1999). https://doi.org/10.1007/BF02493626
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DOI: https://doi.org/10.1007/BF02493626