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Reversed-phase separations on cellulose tris(3,5-dimethylphenylcarbamate) chiral stationary phase

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Summary

The chiral separation of eight racemic compounds has been investigated on a cellulose tris(3,5-dimethylphenylcarbamate) chiral column under reversed-phase conditions. The discrimination mechanism under reversed-phase conditions is discussed. Addition of acid to the mobile phase is necessary for resolution of acidic racemic compounds. The presence of ion-pair reagent in the mobile phase is a key factor in the resolution of basic racemic compounds. Retention of the racemates is also affected by addition of acid or salt. The anion in buffer not only interacts with the racemete, but also with the polysaccharide derivative on the silica gel surface.

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Authors and Affiliations

  1. Institute of Chemistry, Northwest Normal University, 730070, Lanzhou, P.R. China

    J. G. Hou, X. Q. Han, J. Z. Gao & J. W. Kang

  2. Department of Chinese Herbs, Gansu Chinese Medicine College, 730000, Lanzhou, P.R. China

    Y. L. Wang

  3. Department of Chemistry, Guizhou Normal University, 550001, Guiyang, P.R. China

    C. X. Li

Authors
  1. J. G. Hou
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  2. Y. L. Wang
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  3. C. X. Li
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  4. X. Q. Han
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  5. J. Z. Gao
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  6. J. W. Kang
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Hou, J.G., Wang, Y.L., Li, C.X. et al. Reversed-phase separations on cellulose tris(3,5-dimethylphenylcarbamate) chiral stationary phase. Chromatographia 50, 89–95 (1999). https://doi.org/10.1007/BF02493623

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  • DOI: https://doi.org/10.1007/BF02493623

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