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Comparison of LC-UV and LC-MS-MS for the determination of taxol

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Summary

The relative advantages of LC-UV and LC-MS-MS methodologies for taxol as applied to toxicokinetic and pharmacokinetic studies is reviewed and some specific applications of the two methods used in our laboratories compared. The LC-MS-MS method was found to be twenty-five times more sensitive than the LC-UV method. In essence where plasma concentrations are high and rapid turn round of data is not required the use of the LC-UV is more than adequate. However if sensitivity is an issue, limited amounts of plasma are available and/or where tight deadlines are pivotal LC-MS-MS is the method of choice.

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Authors and Affiliations

  1. Huntingdon Life Sciences, Woolley Road, Alconbury, PE28 4HS, Huntingdon, Cambs, UK

    S. F. Baldrey, R. R. Brodie, G. R. Morris, E. H. Jenkins & S. T. Brookes

Authors
  1. S. F. Baldrey
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  2. R. R. Brodie
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  3. G. R. Morris
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  4. E. H. Jenkins
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  5. S. T. Brookes
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Additional information

Presented at: 14th International Bioanalytical Forum: Sensitive Bioanalysis in Anti-cancer and other Drug Areas, Guildford, UK, Jul 3–6, 2001

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Baldrey, S.F., Brodie, R.R., Morris, G.R. et al. Comparison of LC-UV and LC-MS-MS for the determination of taxol. Chromatographia 55 (Suppl 1), S187–S192 (2002). https://doi.org/10.1007/BF02493378

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  • DOI: https://doi.org/10.1007/BF02493378

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