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A case of spontaneous regression of hepatocellular carcinoma with multiple lung metastases

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Abstract

Spontaneous regression of hepatocellular carcinoma (HCC) is a rare phenomenon. We present herein the case of a patient with hepatocellular carcinoma with multiple lung metastases in whom malignancy spontaneously regressed after takingPhellinus linteus Mycelium. A 79-year-old man consulted our hospital complaining of epigastric discomfort. Abdominal MRI and CT revealed a 3 cm diameter tumor in the liver, and chest CT showed numerous nodular lesions. The levels of alpha-fetoprotein (AFP) and protein induced by vitamin K deficiency or antagonist-II (PIVKA-II) were very high. We diagnosed HCC with multiple lung metastases, and no therapy was performed. Independently he took exact fromPhellinus linteus Mycelium for one month, and 6 months later the tumors appeared to be in complete regression. The mechanism underlying this intriguing phenomenon remains unknown.

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References

  1. Cole WH. Efforts to explain spontaneous regression of cancer.J Surg Oncol, 17: 201–209, 1981.

    PubMed  CAS  Google Scholar 

  2. Kato H, Nakamura M, Muramatsu M, Orito E, Ueda R, Mizokami M. Spontaneous regression of hepatocellular carcinoma: two case reports and a literature review.Hepatol Res, 29: 180–190, 2004.

    Article  PubMed  Google Scholar 

  3. Ikeda M, Okada S, Ueno H, Okusaka T, Kuriyama H. Spontaneous regression of hepatocellular carcinoma with multiple lung metastases: a case report.Jpn J Clin Oncol, 31: 454–458, 2001.

    Article  PubMed  CAS  Google Scholar 

  4. Nakai T, Shinomura T, Nakai H. A case of three years disease free survival after spontaneous regression without any treatment for recurrent hepatocellular carcinoma Evaluation of NK cell activity with bibliographical review.J Wakayama Med Soc, 53: 197–201, 2002.

    Google Scholar 

  5. Nakai T, Shimomura T, Hirokawa F. Spontaneous regression of recurrent hepatocellular carcinoma after TAE: possible mechanisms of immune mediation.Int J Clin Oncol, 6: 149–152, 2001.

    Article  PubMed  CAS  Google Scholar 

  6. Abiru S, Kato Y, Hamasaki K, Nakao K, Nakata K, Eguchi K. Spontaneous regression of hepatocellular carcinoma associated with elevated levels of interleukin 18.Am J Gastroenterol, 97: 774–775, 2002.

    Article  PubMed  Google Scholar 

  7. Iyoda Kenya, Sasaki Yutaka, Hayashi Norio. Apoptosis and Signal Transduction in Liver Disease.Saishin Igaku, 57:42–46, 2002.

    Google Scholar 

  8. Ikekawa T, Nakanishi M, Uehara N, Chihara G, Fukuoka F. Antitumor action of some Basidiomycetes, especially Phllinus Linteus.Gann, 59: 155–157, 1968.

    PubMed  CAS  Google Scholar 

  9. Ishibashi H, Komiyama M, Maruyama N, Abe S, Yamaguchi H. Immunological activation of macrophages and lymphocytes in mice intraperitoneally administered with a Phllinus linteus preparation.Pharmacometrics, 65: 35–38, 2003.

    CAS  Google Scholar 

  10. Han SB, Lee CW, Jeon YJ,et al. The inhibitory effect of polysaccharides isolated from Phellinus linteus on tumor growth and metastasis.Immunopharmacology, 41: 157–164, 1999.

    Article  PubMed  CAS  Google Scholar 

  11. Kim HM, Han SB, Oh GT,et al. Stimulation of humoral and cell mediated immunity by polysaccharide from mushroom Phellinus linteus.Int J Immunopharmacol, 18: 295–303, 1996.

    Article  PubMed  CAS  Google Scholar 

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Kojima, H., Tanigawa, N., Kariya, S. et al. A case of spontaneous regression of hepatocellular carcinoma with multiple lung metastases. Radiation Medicine 24, 139–142 (2006). https://doi.org/10.1007/BF02493281

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  • DOI: https://doi.org/10.1007/BF02493281

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