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Direct separation of the enantiomers of cetirizine and related compounds by reversed-phase chiral HPLC

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Summary

Direct separations of the enantiomers of cetirizine and related compounds have been achieved by reversed-phase HPLC on the Chiralcel OD-R, a polysaccharide-derived chiral stationary phase; the mobile phase was usually perchlorate solution supplemented with acetonitrile. Resolution of the enantiomers of cetirizine and related compounds was good. The effect of the acetonitrile content of the mobile phase was investigated, and the effect of the structure of the chiral compounds on their behavior on the Chiralcel OD-R column is discussed.

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References

  1. Juhlin, L.; De Vos, C.; Pierre R.,J. Allergy Clin. Immunol. 1987,80, 599–602.

    Article  CAS  Google Scholar 

  2. Coulie, P.J.; Ghys, L.; Rihoux, J.P.,J. Int. Med. Res.,1991,19, 174–179.

    CAS  Google Scholar 

  3. Chem. Eng. News 1992,70, 5.

  4. Bakker, R.A.; Wieland, K.; Timmerman, H.; Leurs, R.,Eur. J. Pharmacol. 2000,387, R5-R7.

    Article  CAS  Google Scholar 

  5. Gray, N.M.1997, US Patent 5627183.

  6. Pflum, D.A.; Krishnamurthy, D.; Han, Z.; Wald, S.A.; Senanayake, C.H.Tetrahedron Lett. 2002,43, 923–926.

    Article  CAS  Google Scholar 

  7. Pflum, D.A.; Wilkinson, H.S.; Tanoury, G.J.; Kessler, D.W.; Kraus, H.B.; Senanayake, C.H.; Wald, S.A.;Org. Process Res. Dev. 2001,5, 110–115.

    Article  CAS  Google Scholar 

  8. Bonato, P.S., Ricci Jr. E.; Carvalho, R.,J. Liq. Chromatogr. Related Technol. 1999,22(12), 1813–1827.

    Article  CAS  Google Scholar 

  9. Penmetsa, K.V.; Reddick, C.D.; Fink, S.W.; Kleintop, B.L.; Didonato, G.C.; Volk, K.J.; Klohr, S.E.J. Liq. Chromatogr. Related Technol. 2000,23, 831–839.

    Article  CAS  Google Scholar 

  10. Clemo, G.C.; Gardner, C.; Raper, R.J. Chem. Soc. 1939, 1958–1960.

  11. Pichini, S.; Pacifici, R., Altieri, I.; Pellegrini, M.; Zuccaro, P.J. Liq. Chromatogr. Related Technol. 1996,19, 1927–1935.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Chemistry and Chemical Engineering, Hebei Normal University, 050091, Hebei, Shijiazhuang, P.R. China

    Q. Liu, Z. Zhang & H. Bo

  2. Laboratory of Biocatalysis and Organic Chemistry, Delft University of Technology, Julianalaan 136, 2628BL, Delft, The Netherlands

    Q. Liu & R. A. Sheldon

Authors
  1. Q. Liu
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  2. Z. Zhang
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  3. H. Bo
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  4. R. A. Sheldon
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Liu, Q., Zhang, Z., Bo, H. et al. Direct separation of the enantiomers of cetirizine and related compounds by reversed-phase chiral HPLC. Chromatographia 56, 233–235 (2002). https://doi.org/10.1007/BF02493218

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  • DOI: https://doi.org/10.1007/BF02493218

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