Summary
A gas chromatographic method for the determination of residues of Fosfomycin in chicken muscle samples has been developed. Muscle samples were homogenised with TRIS buffer, containing phenylphosphonic acid (as internal standard) and Fosfomycin using a tissue homogenizer. Afterwards, the samples were ultrafiltered and the ultrafiltrate was evaporated to dryness. A silylation reagent for derivatization was used in order to reconstitute the residue. The linear concentration range of application was 10–150 μgg−1, with a detection and quantitation limit of 3.11 and 10 μgg−1, respectively. The method was efficient with a mean recovery of 87.83% from spiked muscle. The results obtained show that gas chromatography is a useful method for the determination of Fosfomycin residues in chicken muscle samples.
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Loste, A., Hernández, E., Bregante, M.A. et al. Development and validation of a gas chromatographic method for analysis of fosfomycin in chicken muscle samples. Chromatographia 56, 181–184 (2002). https://doi.org/10.1007/BF02493209
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DOI: https://doi.org/10.1007/BF02493209