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Effect of the structure of organic phosphonate compounds on chiral separations on derivatized cellulose chiral stationary phase

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  • Column Liquid Chromatography
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Summary

The enantiomers of eightO,O-dialkyl-2-benzyloxycarbonylaminoarylmethyl phosphonates have been directly separated on a tris(3,5-dimethylphenylcarbamate) cellulose column. The results are very different from those obtained by separation on anN-(3,5-dinitrobenzoyl)leucine (DNBleu) column. The effect of mobile phase composition and column temperature on retention and enantioselectivity were investigated. The effect on chiral separation of the length of, and steric hindrance by, alkoxyl groups of the phosphonate ester and of the nature of the substitutentsp-Cl andp-H on the benzene ring attached to the chiral carbon atom are also discussed.

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Authors and Affiliations

  1. Department of Chemistry, Shandong University, 250100, Jinan, P.R. China

    Guo-Sheng Yang, Lan Zhou, Du Wei & Gao-Lan Li

  2. Department of Analytical Chemistry, University of Almeria, La Cañada de San Urbano, 04120, Almeria, Spain

    Guo-Sheng Yang, P. Parrilla vazquez & A. Garrido Frenich

Authors
  1. Guo-Sheng Yang
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  2. Lan Zhou
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  3. Du Wei
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  4. Gao-Lan Li
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  5. P. Parrilla vazquez
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  6. A. Garrido Frenich
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Yang, GS., Zhou, L., Wei, D. et al. Effect of the structure of organic phosphonate compounds on chiral separations on derivatized cellulose chiral stationary phase. Chromatographia 56, 143–145 (2002). https://doi.org/10.1007/BF02493202

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  • DOI: https://doi.org/10.1007/BF02493202

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