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Journal of Orthopaedic Science

, Volume 2, Issue 3, pp 137–145 | Cite as

Pathological significance of cilia and centrioles in bone and soft tissue tumors

  • Gerson Gandhi Ganev
Original Articles
  • 56 Downloads

Abstract

The incidence and ultrastructure of rudimentary cilia and free centrioles were examined with a transmission electron microscope in 9481 cells from 74 bone and soft tissue tumors (benign and malignant) and from 11 samples of normal, histologically related tissues. The cilia were rudimentary (nonmotile), with a 9+0 axonemal pattern (occasionally 7+0 or 5+0), lacking the central tubules and two dynein arms of subfiber A, and with elongated shafts and basal structures consisting of two centrioles. Free centrioles appeared in all tissues studied, in general close to the Golgi apparatus. There was a significantly higher incidence of cilia and centrioles in the malignant tumors, compared to the incidence in benign tumors and normal tissues, and there was an inverse correlation between the incidence of cilia and centrioles in malignant tumors. Centrioles were not observed in ciliated cells, nor were cilia observed in cells undergoing mitosis. These findings suggest that neoplasia can lead to an increase in the incidence of cilia and centrioles, and that the increase correlates with the malignancy of a tumor. Consideration of the incidence of cilia and centrioles probably gives a better idea of cell proliferation than consideration of the incidence of cilia only.

Key words

bone and soft tissue tumors ultrastructure cilia 

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Copyright information

© The Japanese Orthopaedic Association 1997

Authors and Affiliations

  • Gerson Gandhi Ganev
    • 1
  1. 1.Department of Orthopaedic SurgeryTeikyo University School of MedicineTokyoJapan

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