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Analysis of multiple primary cancers in patients with urologic cancer

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Abstract

Background

The study of the clinical features of multiple primary cancers (MPC) may provide insight into the pathogenesis of specific cancers, as well as the issue of treatment-related induction of second tumors.

Methods

Between 1972 and 1995, 94 of 765 patients with urologic cancer treated at our hospital had MPC. We retrospectively analyzed the clinical features of these patients, and compared them with those of the 671 patients with single primary cancers (SPC).

Results

The frequency of MPC among all 765 patients was 12.3%. The average age at diagnosis of urologic cancer in the male patients was significantly higher in the MPC group than in the SPC group. In the MPC group, the organs most commonly involved were the bladder and prostate (urologic cancers), and the stomach and lung (nonurologic cancers). Adenocarcinoma was the most common tumor in the MPC group. The interval between the first and second cancer diagnoses was significantly longer in female patients with MPC than in male patients. No significant difference between the MPC and SPC groups was observed in the distribution of ABO blood groups or in the frequency of history of tobacco or alcohol use. Four MPC patients had second cancers considered to have been induced by the treatment for the first cancer. The prognoses were significantly poorer for the patients with MPC. The rate of death due to urologic cancer was much lower in the patients with MPC than in those with SPC.

Conclusions

We found that more than 10% of the 765 patients with urologic cancer whose cases we reviewed had another primary cancer. Because the number of cases of MPC is increasing, it is important to be aware of the possibility of the development of MPC and to therefore carefully follow up cancer patients.

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Authors and Affiliations

  1. Myuzumi Clinic, Oizumi, Japan

    Takuji Mayuzumi

  2. Department of Urology, Kurosawa Hospital, Takasaki, Japan

    Fuminari Kumasaka

  3. Iizuka Clinic, Takasaki, Japan

    Toshihiro Shimizu

  4. Department of Urology, Gunma Cancer Center, 617-1 Takabayashi-Nishi, 373, Ota, Gunma, Japan

    Seiji Nakata, Yuichi Kato & Jin Sato

Authors
  1. Seiji Nakata
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  2. Yuichi Kato
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  3. Jin Sato
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  4. Takuji Mayuzumi
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  5. Fuminari Kumasaka
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  6. Toshihiro Shimizu
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Nakata, S., Kato, Y., Sato, J. et al. Analysis of multiple primary cancers in patients with urologic cancer. Int J Clin Oncol 2, 40–46 (1997). https://doi.org/10.1007/BF02492596

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  • DOI: https://doi.org/10.1007/BF02492596

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