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Synthesis and the reversed-phase HPLC analysis ofcis andtrans-dichlorobis(ethylenediamine-ruthenium) chloride isomers

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Summary

In this work we report the monitoring of the synthesis ofcis andtrans-dichlorobis(ethylenedia-mine)ruthenium chloride isomers by HPLC. The preparation of thecis andtrans complexes were as described in the literature with modifications arising from reversed-phase HPLC results. Thecis andtrans complexes were separated with retention times of 3.0 min and 5.5 min respectively using an ODS column (250 mm×4.6 mm i.d. 5 μm particles, Alltech) and methanol/water 45/55 ratio as mobile phase. According to HPLC results the reaction time to completion is 48 h and not 72 h as previously described. The shorter time resulted in better yield 82% and reduced by-products.

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  1. Departmento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Caixa Postal 12.200, CEP: 60455-760, Fortaleza, CE, Brazil

    N. S. Gonçalves, L. C. G. Vasconcellos & S. E. Mazzetto

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  1. N. S. Gonçalves
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  2. L. C. G. Vasconcellos
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  3. S. E. Mazzetto
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Gonçalves, N.S., Vasconcellos, L.C.G. & Mazzetto, S.E. Synthesis and the reversed-phase HPLC analysis ofcis andtrans-dichlorobis(ethylenediamine-ruthenium) chloride isomers. Chromatographia 57, 549–552 (2003). https://doi.org/10.1007/BF02492557

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  • DOI: https://doi.org/10.1007/BF02492557

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