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Identification of isopropyl substituted β-blocking agents in human urine by gas chromatography and tandem mass spectrometry

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Summary

A method for the sensitive detection of isopropyl substituted β-blocking agents in human urine is presented. The sample preparation step involves enzymatic hydrolysis, solid phase extraction and derivatisation withN-methyl-N-trimethylsilyl-trifluoroacetamide. The instrumental analysis was performed using gas chromatography-mass spectrometry with an ion trap mass spectromeler. The mass spectrometer was operated in the scan as well as in the MS-MS mode.

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Authors and Affiliations

  1. Doping Control Laboratory, Chemical Analysis, ARC Seibersdorf Research GmbH, 2444, Seibersdorf, Austria

    G. Forsdahl, T. Geisendorfer & G. Gmeiner

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  1. G. Forsdahl
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  2. T. Geisendorfer
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  3. G. Gmeiner
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Forsdahl, G., Geisendorfer, T. & Gmeiner, G. Identification of isopropyl substituted β-blocking agents in human urine by gas chromatography and tandem mass spectrometry. Chromatographia 57, 519–524 (2003). https://doi.org/10.1007/BF02492551

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  • DOI: https://doi.org/10.1007/BF02492551

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