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Influence of various factors on the chromatographic behavior of cytostatic antibiotics of rubomicin derivatives in micellar liquid chromatography

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Summary

Micellar liquid chromatography has been adopted for separation of cytostatic antibiotics of rubomicin derivatives. The influence of the kind of organic modifier (normal and iso-alcohols) and its concentration, sodium dodecyl sulfate micelle concentration and column temperature on the chromatographic characteristics of rubomicin derivatives have been investigated. 1-pentanol and iso-propanol were shown to be the most suitable for providing optimum selectivity, good tailing factor and column efficiency with minimum reagent consumption.

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Authors and Affiliations

  1. Laboratory of Pharmacopoeial Analysis, Scientific and Expert Pharmacopoeial Centre, Astronomicheskaya Street 33, 61085, Kharkov, Ukraine

    A. U. Kulikov

  2. Department of Chemical Metrology, V.N. Karazin Kharkov National University, Svoboda square, 4, 61077, Kharkov, Ukraine

    L. P. Loginova & L. V. Samokhina

Authors
  1. A. U. Kulikov
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  2. L. P. Loginova
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  3. L. V. Samokhina
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Kulikov, A.U., Loginova, L.P. & Samokhina, L.V. Influence of various factors on the chromatographic behavior of cytostatic antibiotics of rubomicin derivatives in micellar liquid chromatography. Chromatographia 57, 463–469 (2003). https://doi.org/10.1007/BF02492542

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  • DOI: https://doi.org/10.1007/BF02492542

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