Ultra thin-layer chromatography
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Ultra thin-layer chromatography plates (UTLC) with a monolithic structure of the stationary silica gel phase open up a new dimension in modern planar chromatography. The extremely small layer thickness of 10 μm and the absence of any kind of a binder lead, in combination with the structure of this stationary phase, to new and improved properties of the UTLC silica gel plates. The advantages of these UTLC plates are the short migration distances in the range of 1–3 cm, the short development times as well as the very low consumption of solvents as mobile phases in combination with high separation efficiency and sensitivity.
The possibilities of the ultra thin-layer silica gel plates are demonstrated by separations of pharmaceutically active ingredients, phenols, plasticisers, and steroids.