Chromatographia

, Volume 56, Issue 7–8, pp 439–444 | Cite as

The special effect of fluoride on the chromatography of acidic analytes on polybutadiene-coated zirconia

  • Y. Hu
  • P. W. Carr
Originals Column Liquid Chromatography

Summary

The special effect of fluoride as a Lewis base additive in suppressing the ligand-exchange interactions for acidic analytes on polybutadiene-coated zirconia (PBD-ZrO2) has been investigated. We found that fluoride is more effective than phosphate in improving the separation efficiency for strong acids. The improvement is attributed to that fluoride has a smaller size and a more flexible coordination chemistry towards zirconium centers than phosphate; consequently, fluoride can more effectively improve the kinetics of the ligand-exchange processes for strongly acidic analytes. We demonstrated that using a small amount of fluoride in combination with a larger quantity of phosphate is a practical way to improve the separation efficiency and resolution for acidic analytes. Some example separations are presented.

Key Words

Column liquid chromatography Polybutadiene-coated zirconia Ligand-exchange interaction Fluoride eluent Acidic analytes 

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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 2002

Authors and Affiliations

  • Y. Hu
    • 1
  • P. W. Carr
    • 1
  1. 1.Department of ChemistryUniversity of MinnesotaMinneapolisUSA

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