Summary
Permethyl monoamino β-cyclodextrin, a new chiral selector, has been synthesized and tested as a chiral discriminating agent in capillary electrophoresis. This agent is suitable for separation of both negatively and positively charged as well as neutral enantiomers. At various concentrations of permethyl monoamino β-cyclodextrin, stable electroosmotic flow was measured in a cathodic direction. Due to the high solubilizing power and low conductivity of permethyl monoamino β-cyclodextrin efficiencies of up to 600 000 theoretical plates efficiency could be obtained. This high efficiency resulted in baseline separations of enantiomers resolved by a separation factor of only 1.009.
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This paper is dedicated to the memory of Dr. Tibor Tóth.
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Iványi, R., Jicsinszky, L. & Juvancz, Z. Permethyl monoamino β-cyclodextrin a new chiral selective agent for capillary electrophoresis. Chromatographia 53, 166–172 (2000). https://doi.org/10.1007/BF02491565
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DOI: https://doi.org/10.1007/BF02491565