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Separation of enantiomers on bovine serum albumin coated zirconia in reversed-phase liquid chromatography

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Summary

Zirconia is known to be one of the best materials for the chromatographic support due to its excellent chemical, thermal and mechanical stability. In this work we report preparation and use of bovine serum albumin (BSA)-immobilized zirconia as a chiral stationary phase for separation of some enantiomers in reversed-phase liquid chromatography. The BSA-zirconia showed good enantioselectivity for some of the enantiomers studied and could be used for RPLC separations in mobile phases of alkaline pH.

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Authors and Affiliations

  1. Department of Chemistry, Yeungnam University, 712-749, Kyongsan, Korea

    J. H. Park, J. K. Ryu & J. K. Park

  2. Zirchrom Separations, Inc., 55303, Anoka, MN, USA

    C. V. McNeff

  3. Department of Chemistry, University of Minnesota, 55455, Minneapolis, MN, USA

    P. W. Carr

Authors
  1. J. H. Park
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  2. J. K. Ryu
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  3. J. K. Park
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  4. C. V. McNeff
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  5. P. W. Carr
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Park, J.H., Ryu, J.K., Park, J.K. et al. Separation of enantiomers on bovine serum albumin coated zirconia in reversed-phase liquid chromatography. Chromatographia 53, 405–408 (2001). https://doi.org/10.1007/BF02491075

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  • DOI: https://doi.org/10.1007/BF02491075

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