, Volume 53, Issue 7–8, pp 405–408 | Cite as

Separation of enantiomers on bovine serum albumin coated zirconia in reversed-phase liquid chromatography

  • J. H. Park
  • J. K. Ryu
  • J. K. Park
  • C. V. McNeff
  • P. W. Carr
Originals Column Liquid Chromatography


Zirconia is known to be one of the best materials for the chromatographic support due to its excellent chemical, thermal and mechanical stability. In this work we report preparation and use of bovine serum albumin (BSA)-immobilized zirconia as a chiral stationary phase for separation of some enantiomers in reversed-phase liquid chromatography. The BSA-zirconia showed good enantioselectivity for some of the enantiomers studied and could be used for RPLC separations in mobile phases of alkaline pH.

Key Words

Column liquid chromatography Bovine serum albumin Zirconia Stationary phase Chiral separation 


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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 2001

Authors and Affiliations

  • J. H. Park
    • 1
  • J. K. Ryu
    • 1
  • J. K. Park
    • 1
  • C. V. McNeff
    • 2
  • P. W. Carr
    • 3
  1. 1.Department of ChemistryYeungnam UniversityKyongsanKorea
  2. 2.Zirchrom Separations, Inc.AnokaUSA
  3. 3.Department of ChemistryUniversity of MinnesotaMinneapolisUSA

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