Skip to main content
SpringerLink
Log in

Analysis of the compounds in the synthesis mixtures of hydroxy acids by a gradient programmed RP-HPLC with UV/vis and RI detectors

  • Originals
  • Column Liquid Chromatography
  • Published:
Chromatographia Aims and scope Submit manuscript

Summary

A gradient programmed reversed phase high-performance liquid chromatographic (RP-HPLC) method is described for the quantitative determination of some aldehydes, hydroxy aldehydes, unsaturated aldehydes, hydroxy carboxylic acids, carboxylic acids, alcohols and polyols using an ultraviolet and a refractive index detector in series. The sample matrices are synthesis mixtures of hydroxy carboxylic acids. The structures of the hydroxy aldehyde intermediates are determined by13C NMR and the influence of sample preparation on analysis results is discussed. The limits of detection and the precision of the method are evaluated.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Tanaka, T.; Kuroda, T.Yuki Gosei Kagaku Kyokaishi 1978,36(12), 1095.

    CAS  Google Scholar 

  2. Maki, T.; Kawakami, I.JP,1995, 45430.

  3. BASF,Ger. Pat. 857802, Chem. Abstr. 1956,50, 5020h.

    Google Scholar 

  4. Chemische Werke Albert,Brit. Pat. 730759, Chem. Abstr. 1956,50, 12101g.

    Google Scholar 

  5. Pappa, D.; Zamfirescu, T.Rom. Pat. 57269, Chem. Abstr. 1975,83, 192548.

    Google Scholar 

  6. Jelinek, J.Czech. Pat. 161450, Chem. Abstr. 1976,85, 93805.

    Google Scholar 

  7. Bude, H.J.; Dietze, H.; Funke, C.; Hauthal, H.G.; Hemmann, S.; Heyner, E.; Lichtenfeld, K.; Kloss, R.; Kohlert, G. Ger. (East) Pat. 134514,Chem. Abstr. 1979,91, 38916.

    Google Scholar 

  8. Doi, K.; Murakami, S.; Tanaka, N.JP,1994, 06192169.

  9. Noack, W.; Daute, P.; Hees, U.DE 1995, 4328428.

  10. Heathcock, C.H. “The Aldol Reaction” inComprehensive Organic Synthesis: Selectivity, Strategy and Efficiency in Modern Organic Chemistry, Trost, B.M.; Fleming, I. Eds. Oxford:Pergamon Press 1991,2, 133.

    Google Scholar 

  11. Wiersma, D.S.; Hoyle, R.E.; Rempis, H.Anal. Chem. 1962,34, 1533.

    Article  CAS  Google Scholar 

  12. Vik, J. -E.Acta Chemica Scandinavica 1974,B28, 509.

    Article  CAS  Google Scholar 

  13. Oesterhelt, G.; Pozeg, M.; Bubendorf, A.; Bartoldus, D.Fresenius Z. Anal. Chem. 1985,321, 553.

    Article  CAS  Google Scholar 

  14. Koivusalmi, E.; Haatainen, E.; Root, A.Anal. Chem. 1999,71, 86.

    Article  CAS  Google Scholar 

  15. Cairati, L.; Cannizzaro, M.; Comini, A.; Gatti, G.; Vita-Finzi, P.J. Chromatogr. 1981,216, 402.

    Article  CAS  Google Scholar 

  16. Koivusalmi, E.; Hakanpää-Laitinen, H.; Haatainen, E.; Saarela, T.; Kilpeläinen, I.,Chromatographia 2000,52, 22–26.

    CAS  Google Scholar 

  17. Shay, J.F.; Skilling, S.; Stafford, R.W.Anal. Chem. 1954,26, 652.

    Article  CAS  Google Scholar 

  18. Svarcs, E.M.; Kalve, I.V.; Ievins, A.F.Latvijas PSR Zinatnu Akad. Vestis 1975, 4501.

  19. Tou, J.C.Org. Mass Spectrom. 1972,6, 833.

    Article  CAS  Google Scholar 

  20. Cairati, L.; Cannizzaro, M.; Comini, A.; Gatti, G.; Pasquon, I.; Vita-Finzi, P.Chim. Ind. (Milan)1981,63, 723.

    CAS  Google Scholar 

  21. March, J.Advanced Organic Chemistry Reactions, Mechanisms, and Structure, 3rd ed., John Wiley & Sons, New York, 1985, Chapter 10, p. 329.

    Google Scholar 

  22. Burke, S.Sci. Data Manag. 1997,1, no 4, 33.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Fortum Oil and Gas Oy, Scientific Services, Analytical Research, P.O.B. 310, 06101, Porvoo, Finland

    E. Koivusalmi, T. Saarela & A. Root

  2. Neste Chemicals Oy, P.O.B. 310, 06101, Porvoo, Finland

    E. Karvinen

Authors
  1. E. Koivusalmi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. Saarela
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Root
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. Karvinen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Koivusalmi, E., Saarela, T., Root, A. et al. Analysis of the compounds in the synthesis mixtures of hydroxy acids by a gradient programmed RP-HPLC with UV/vis and RI detectors. Chromatographia 52, 27–32 (2000). https://doi.org/10.1007/BF02490788

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02490788

Key Words

Search

Navigation