Summary
RP-HPLC and GC methods are described for the determination of the compounds in synthesis mixtures of 2,2-dimethyl-3-hydroxypropionaldehyde (DHPAL). Special attention is paid to the analysis of DHPAL. Conditions for analysis are developed so that no derivatization is needed despite the equilibrium reactions typical of hydroxy aldehydes. Different solvent matrices, pH and sample concentrations are tested in sampling and analysis. Linearity of the calibration lines and precision of the methods are evaluated for all compounds. Detection limits of different compounds are calculated for both methods.
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Koivusalmi, E., Hakanpää-Laitinen, H., Haatainen, E. et al. Quantitative analysis of the compounds in synthesis mixtures of 2,2-dimethyl-3-hydroxypropionaldehyde by RP-HPLC and GC. Chromatographia 52, 22–26 (2000). https://doi.org/10.1007/BF02490787
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DOI: https://doi.org/10.1007/BF02490787