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Solid-phase microextraction/capillary gas chromatography for the profiling of confiscated ecstacy and amphetamine

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Summary

Impurity profiling of ecstacy and amphetamine seizures was accomplished by solid-phase microextraction (SPME) combined with capillary gas chromatography (GC). Samples were dissolved in 0.1 M aqueous acetate buffer (pH 5.0) as the only manual operation and subsequently subjected to SPME-GC. Ecstacy tablets were analyzed by head-space SPME to avoid contamination of SPME fibers with insoluble tablet components, while illicit amphetamine powders were exposed to immersed SPME. A SPME fiber of polydimethylsiloxane-divinylbenzene was found to provide excellent extraction of both polar and non-polar impurities. For both illicit ecstacy and amphetamine, complex impurity profiles were obtained by SPME providing a high information content. For ecstacy, profiles (relative peak areas) were repeatable within 2.2 to 12.6% RSD (n=6) while similar data on amphetamine varied between 2.0 and 10.9% RSD (n=6). No carry-over was observed although each fiber was used for 50 to 100 extractions.

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Authors and Affiliations

  1. School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, 0316, Oslo, Norway

    K. E. Kongshaug, S. Pedersen-Bjergaard, K. E. Rasmussen & M. Krogh

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  1. K. E. Kongshaug
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  2. S. Pedersen-Bjergaard
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  3. K. E. Rasmussen
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  4. M. Krogh
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Kongshaug, K.E., Pedersen-Bjergaard, S., Rasmussen, K.E. et al. Solid-phase microextraction/capillary gas chromatography for the profiling of confiscated ecstacy and amphetamine. Chromatographia 50, 247–252 (1999). https://doi.org/10.1007/BF02490660

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  • DOI: https://doi.org/10.1007/BF02490660

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