Chromatographia

, Volume 53, Supplement 1, pp S442–S444 | Cite as

Salting-out thin-layer chromatography of some angiotensin converting enzyme inhibitors on different sorbents

  • M. B. Aleksić
  • D. G. Agbaba
  • D. M. Milojković-Opsenica
  • Ž. Lj. Tešić
Originals Thin-Layer Chromatography

Summary

Chromatographic behaviour of six antihypertensive drugs from the class ofACE inhibitors was studied under conditions of salting-out thin-layer chromatography on silica-gel, cellulose and polyacrylonitrile (PANS) as sorbents. For this purpose, different concentrations of aqueous ammonium sulphate solutions were used as solvents. In all cases studied, it was established that hR F values decrease with increasing salt concentrations in the chromatographic solvent systems used. In addition, a linear relationship of the correspondingR M values and ammonium sulphate content in the solvent was observed. To explain these results, a separation mechanism based on hydrophobic interaction between the sorbent and sorbent is proposed.

Key Words

Thin-layer chromatography Salting-out ACE inhibitors Polyacrylonitrile sorbent Silica-gel Cellulose 

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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 2001

Authors and Affiliations

  • M. B. Aleksić
    • 1
  • D. G. Agbaba
    • 1
  • D. M. Milojković-Opsenica
    • 2
  • Ž. Lj. Tešić
    • 2
  1. 1.Faculty of PharmacyUniversity of BelgradeBelgradeYugoslavia
  2. 2.Faculty of ChemistryUniversity of BelgradeBelgradeYugoslavia

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