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Evaluation of the antimicrobial activity of carbapenem and cephem antibiotics againstPseudomonas aeruginosa isolated from hospitalized patients

  • Kenji Nishizawa
  • Masaaki Hirano
  • Akio Kimura
  • Toru Mochizuki
  • Yasuhiro Yamamoto
  • Shigeo Yamamura
  • Yasunori Momose
Original Articles

Abstract

Pseudomonas aeruginosa is an opportunistic pathogen that infects compromised hosts. It is therefore important to clarify the bactericidal activity of antimicrobial agents against this bacterium. We evaluated the antimicrobial potency of several antibiotics againstP. aeruginosa by measuring the MIC and the minimum bactericidal concentration (MBC). Imipenem, panipenem meropenem, ceftazidime, cefpirome, cefepime, and cefozopran were the antibiotics evaluated. The 40 strains ofP. aeruginosa used in this analysis were isolated from the sputum of 40 patients. The MIC was determined by the microbroth dilution method. Afterwards, we determined the MBC, which is the lowest concentration of antibiotic at which all bacteria in the diluted culture are killed. The MIC and MBC of meropenem was determined to be 2 to 8 times lower and 2 to 4 times lower, respectively, than those of other carbapenem antibiotics tested. The MIC and MBC of cefozopran were determined to be 2 to 16 times lower and 4 to 16 times lower, respectively, than those of other cephem antibiotics tested. Meropenem and cefozopran show the greatest bactericidal activity againstP. aeruginosa among the, carbapenem and cephem antibiotics tested. Meropenem would be one of the best selections for treatment of pyocyanic infections in immunocompromised patients, because it also provides a postantibiotic effect againstP. aeruginosa.

Key words

Pseudomonas aeruginosa antimicrobial activity MIC minimum bactericidal concentration (MBC) carbapenem cephem 

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Copyright information

© JSC/CLJ 1998

Authors and Affiliations

  • Kenji Nishizawa
    • 1
  • Masaaki Hirano
    • 1
  • Akio Kimura
    • 2
  • Toru Mochizuki
    • 2
  • Yasuhiro Yamamoto
    • 2
  • Shigeo Yamamura
    • 3
  • Yasunori Momose
    • 3
  1. 1.Department of PharmacyNippon Medical School HospitalTokyoJapan
  2. 2.Department of EmergencyNippon Medical School HospitalTokyoJapan
  3. 3.School of Pharmaceutical SciencesToho UniversityChibaJapan

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