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International Journal of Clinical Oncology

, Volume 3, Issue 1, pp 41–43 | Cite as

A case of ovarian endometrioid adenofibroma of borderline malignancy: Evidence for estrogen-producing tumor

  • Etsuko Miyagi
  • Fumiki Hirahara
  • Yoshiaki Inayama
  • Itsuo Gorai
  • Hajime Yamaguchi
  • Tsuneo Nakazawa
  • Yoji Nagashima
  • Yukio Nakatani
  • Hiroshi Minaguchi
  • Hitoshi Kitamura
Case Report
  • 144 Downloads

Abstract

A case of ovarian endometrioid adenofibroma of borderline malignancy with an increased serum estradiol level, which rapidly disappeared after removal of the tumor, is reported. Vaginal cytologic analysis showed estrogenic effects, and endometrial cystic glandular hyperplasia was thought to be the reason for genital bleeding. To determine the origin of estradiol production in the tumor, stromal cells were enzymatically isolated from the tumor and cultured in vitro. Estradiol levels in the cultured media increased in parallel with cell growth. This is the first report showing estrogen secretion from stromal cells in an ovarian endometrioid adenofibroma.

Key words

ovarian adenofibroma of borderline malignancy estrogen secretion cultured stromal cells 

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Copyright information

© JSCO/CLJ 1998

Authors and Affiliations

  • Etsuko Miyagi
    • 1
  • Fumiki Hirahara
    • 1
  • Yoshiaki Inayama
    • 2
  • Itsuo Gorai
    • 1
  • Hajime Yamaguchi
    • 1
  • Tsuneo Nakazawa
    • 1
  • Yoji Nagashima
    • 3
  • Yukio Nakatani
    • 2
  • Hiroshi Minaguchi
    • 1
  • Hitoshi Kitamura
    • 2
  1. 1.Department of Obstetrics and GynecologyYokohama City University School of MedicineYokohamaJapan
  2. 2.Division of Anatomical and Surgical PathologyYokohama City University School of MedicineYokohamaJapan
  3. 3.Department of PathologyYokohama City University School of MedicineYokohamaJapan

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