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A case of ovarian endometrioid adenofibroma of borderline malignancy: Evidence for estrogen-producing tumor

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Abstract

A case of ovarian endometrioid adenofibroma of borderline malignancy with an increased serum estradiol level, which rapidly disappeared after removal of the tumor, is reported. Vaginal cytologic analysis showed estrogenic effects, and endometrial cystic glandular hyperplasia was thought to be the reason for genital bleeding. To determine the origin of estradiol production in the tumor, stromal cells were enzymatically isolated from the tumor and cultured in vitro. Estradiol levels in the cultured media increased in parallel with cell growth. This is the first report showing estrogen secretion from stromal cells in an ovarian endometrioid adenofibroma.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Yokohama City University School of Medicine, Fukuura 3-9, Kanazawa-ku, 236-0004, Yokohama, Japan

    Etsuko Miyagi, Fumiki Hirahara, Itsuo Gorai, Hajime Yamaguchi, Tsuneo Nakazawa & Hiroshi Minaguchi

  2. Division of Anatomical and Surgical Pathology, Yokohama City University School of Medicine, Fukuura 3-9, Kanazawa-ku, 236-0004, Yokohama, Japan

    Yoshiaki Inayama, Yukio Nakatani & Hitoshi Kitamura

  3. Department of Pathology, Yokohama City University School of Medicine, Fukuura 3-9, Kanazawa-ku, 236-0004, Yokohama, Japan

    Yoji Nagashima

Authors
  1. Etsuko Miyagi
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  2. Fumiki Hirahara
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  3. Yoshiaki Inayama
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  4. Itsuo Gorai
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  5. Hajime Yamaguchi
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  6. Tsuneo Nakazawa
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  7. Yoji Nagashima
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  8. Yukio Nakatani
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  9. Hiroshi Minaguchi
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  10. Hitoshi Kitamura
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Cite this article

Miyagi, E., Hirahara, F., Inayama, Y. et al. A case of ovarian endometrioid adenofibroma of borderline malignancy: Evidence for estrogen-producing tumor. Int J Clin Oncol 3, 41–43 (1998). https://doi.org/10.1007/BF02490101

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  • DOI: https://doi.org/10.1007/BF02490101

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