Abstract
We measured concentrations of interleukin-1β,-6 and-8, and tumor necrosis factor-α in the urine and blood of patients with urinary tract infections. We also examined the relationships between the severity of pyuria and concentrations of interleukin-6 or interleukin-8 in urine. Concentrations of interleukin-6 and-8 were significantly higher in the urine of patients with urinary tract infections than that of healthy subjects or patients with fever unrelated to the urinary tract infection. A close relationship was observed between the severity of pyuria and the concentration of interleukin-8. Concentrations of interleukin-6 and-8 in the blood were higher in patients with pyelonephritis than in patients with cystitis. These results suggest that the interleukin-6 and-8 were generated in the urinary tract during pyelonephritis and cystitis, and that the interleukin-8 induced leukocyte influx into the urine.
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Sakumoto, M., Matsumoto, T., Mochida, O. et al. Urinary concentrations of cytokines in patients with pyelonephritis and cystitis. J Infect Chemother 4, 24–27 (1998). https://doi.org/10.1007/BF02490062
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DOI: https://doi.org/10.1007/BF02490062