Abstract
We examined the MIC of mupirocin againstStaphylococcus aureus strains isolated from skin infections between April 1996 and August 1997. None of the 32S. aureus strains collected between April 1996 and September 1996 showed mupirocin-resistance, but 3 of the 58S. aureus strains collected between October 1996 and August 1997 were found to be mupirocin-resistant with a MIC of 32 μg/mL. The 3 patients from whom the mupirocin-resistantS. aureus strains were isolated were outpatients with no previous mupirocin ointment treatment. The 3 mupirocin-resistantS. aureus strains were regarded as different strains on the basis of their coagulase typing, enterotoxin production, and antibiotic sensitivity. Our results suggest that the emergence of mupirocin-resistantS. aureus should be carefully monitored in Japan. Mupirocin ointment should be used only to eradicate nasal carriage of methicillin-resistantS. aureus and long-term use of the ointment should be strictly avoided.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Rahman M, Noble WC, Cookson B. Mupirocin-resistantStaphylococcus aureus. Lancet 1987;2:387.
Cookson BD, Lacey RW, Noble WC, Reeves DS, Wise R, Redhead RJ. Mupirocin-resistantStaphylococcus aureus. Lancet 1990;335:1095–1096.
Japanese Society for Chemotherapy. Method for the determination of minimum inhibitory concentration (MIC) of bacteria by microdilution method (in Japanese). Chemotherapy 1990;38:102–105.
Baird D, Coia J. Mupirocin-resistantStaphylococcus aureus. Lancet 1987;2:387–388.
Gilbart J, Perry CR, Slocombe B. High-level mupirocin resistance inStaphylococcus aureus: evidence for two distinct isoleucyl-tRNA synthetase. Antimicrob Agents Chemother 1993;37:32–38.
Reagan DR, Doebbeling BN, Pfaller MA, Sheetz CT, Houston AK, Hollis RJ, et al. Elimination of coincidentStaphylococcus aureus nasal and hand carriage with intranasal application of mupirocin ointment. Ann Intern Med 1991;114:101–106.
Doebbeling BN, Reagan DR, Pfaller MA, Houston AK, Hollis RJ, Wenzel RP. Long-term efficacy of intranasal mupirocin ointment. Arch Intern Med 1994;154:1505–1508.
Ubukata K, Sugiura M, Konno M, Kunii O, Okinaga K, Kobayashi K, et al. Clinical evaluation of mupirocin nasal ointment on nasal carriage ofStaphylococcus aureus (in Japanese). Chemotherapy 1993;41:1125–1138.
Author information
Authors and Affiliations
About this article
Cite this article
Akiyama, H., Yamasaki, O., Kanzaki, H. et al. Detection of mupirocin-resistantStaphylococcus aureus isolated from skin infections. J Infect Chemother 4, 94–96 (1998). https://doi.org/10.1007/BF02489967
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF02489967