Advertisement

International Journal of Clinical Oncology

, Volume 3, Issue 4, pp 253–256 | Cite as

A case of asynchronous development of transitional cell carcinoma in the bladder and renal pelvis after prolonged cyclophosphamide therapy

  • Shoichi Ebisuno
  • Takeshi Inagaki
Case Report

Abstract

Urinary bladder cancers occurring after prolonged cyclophosphamide therapy are being increasingly reported. Cyclophosphamide-induced cancer in the upper urinary tract is not, however, generally recognized. We report a case of asynchronous development of transitional cell carcinoma in the bladder and renal pelvis, after prolonged cyclophosphamide therapy for non-Hodgkin's lymphoma. To date, at least 8 cyclophosphamide-related cancers have been reported in the upper tract. These cases are reviewed briefly.

Key words

cyclophosphamide transitional cell carcinoma bladder renal pelvis 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    McDougal WS, Cramer SF, Miller R. Invasive carcinoma of the renal pelvis following cyclophosphamide therapy for non malignant disease. Cancer 1981;48:691–695.PubMedCrossRefGoogle Scholar
  2. 2.
    Fuchs EF, Kay R, Poole R, Barry JM, Pearse HD. Uroepithelial carcinoma in association with cyclophosphamide ingestion. J Urol 1981;1216:544–545.Google Scholar
  3. 3.
    Schiff HI, Finkel M, Schapria HE. Transitional cell carcinoma of the ureter associated with cyclophosphamide therapy for benign disease: a case report. J Urol 1982;128: 1023–1024.PubMedGoogle Scholar
  4. 4.
    Brenner DW, Schellhammer PF. Upper tract urothelial malignancy after cyclophosphamide therapy: case report and literature review. J Urol 1987;137:1226–1227.PubMedGoogle Scholar
  5. 5.
    Shetty SD, Tabacqchali MA. Cyclophosphamide and ureteric carcinoma. Br J Urol 1987;60:274.PubMedCrossRefGoogle Scholar
  6. 6.
    Cannon J, Linke CA, Cos LR. Cyclophosphamide-associated carcinoma of urothelium: modalities for prevention. Urology 1991;38:413–416.PubMedCrossRefGoogle Scholar
  7. 7.
    Levine E. Transitional cell carcinoma of the renal pelvis associated with cyclophosphamide therapy. Am J Roentgenol 1992;159:1027–1028.Google Scholar
  8. 8.
    Pedersen-Bjergaard J, Ersboll J, Hansen VL, Sorensen BL, Christoffersen K, Hou-Jensen K, Nissen NI, Knudsen JB, Hansen MM. Carcinoma of the urinary bladder after treatment with cyclophosphamide for non-Hodgkin's lymphoma. N Engl J Med 1988;318:1028–1032.PubMedCrossRefGoogle Scholar
  9. 9.
    Talar-Williams C, Hijazi YM, Walther MM, Linehan WM, Hallahan CW, Lubensky I, Kerr GS, Hoffman GS, Fauci AS, Sneller MC. Cyclophosphamide-induced cystitis and bladder cancer in patients with Wegener granulomatosis. Ann Intern Med 1996;124:477–484.PubMedGoogle Scholar
  10. 10.
    Travis LB, Curtis RE, Glimelius B, Holowaty EJ, Van Leeuwen FE, Lynch CF, Hagenbeek A, Stovall M, Banks PM, Adami J. Bladder and kidney cancer following cyclophosphamide therapy for non-Hodgkin's lymphoma. J Natl Cancer Inst 1995;87:524–530.PubMedGoogle Scholar

Copyright information

© JSCO/CLJ 1998

Authors and Affiliations

  • Shoichi Ebisuno
    • 1
  • Takeshi Inagaki
    • 1
  1. 1.Division of UrologyMinami Wakayama National HospitalTanabe-shi, WakayamaJapan

Personalised recommendations