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Clinicopathologic evaluation of mucin-producing tumor of the pancreas

  • Toshiyuki Takahashi
  • Mitsuru Dohke
  • Shun-Ich Okushiba
  • Tomoo Okushiba
  • Hiroyuki Katoh
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Abstract

We studied the diagnostic problems, surgical management, and histopathologic characteristics of 28 patients with intra-ductal tumors and mucinous cystadenomas of the pancreas who underwent surgical resection. Endoscopic ultrasonography (EUS) and endoscopic retrograde pancreatography (ERP) were the most useful means for confident diagnosis of the diseases. New diagnostic modalities, including intra-pancreatic ductal endoscopy and intraductal ultrasonography, also improved the qualitative diagnosis of these tumors. Minimally invasive surgery i.e., duodenum-and choledochus-preserving resection of the head of the pancreas, was conducted in our patients. The long-term results were good and no patients had disease recurrence. Although these diseases are regarded as precancerous lesions of the pancreas, there were several unclear points regarding biologic behavior and the correlation with invasive cystadenocarcinoma. Thus, a molecular biological explanation concerning the roles of oncogenes such asp53 and Ki-ras in carcinogenesis is an important question that remains to be resolved.

Key words

intraductal tumors of the pancreas mucinous cystadenoma of the pancreas p53 duodenum-preserving resection of pancreas head 

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Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • Toshiyuki Takahashi
    • 1
  • Mitsuru Dohke
    • 1
  • Shun-Ich Okushiba
    • 1
  • Tomoo Okushiba
    • 1
  • Hiroyuki Katoh
    • 1
  1. 1.Second Department of SurgeryHokkaido University School of MedicineSapporoJapan

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