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Clinicopathological studies of mucin-producing cholangiocarcinoma

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Journal of Hepato-Biliary-Pancreatic Surgery

Abstract

Cholangiocarcinomas that produced clinically recognizable mucin (mucin-producing cholangiocarcinomas) were studied in ten patients. These ten represented 5.8% of all cholangiocarcinomas resected at our department. All tumors arose from the intrahepatic bile ducts. Macroscopically, the ten tumors were classified as: “ductectatic type” (n=3), in which papillary tumors developed in diffusely dilated intrahepatic bile ducts; “cystic type” (n=5), in which a large cystic tumor was present in the liver; and “intermediate type” (n=2), characterized by a large cystic lesion and a solid mass that infiltrated the liver parenchyma. Histologically, four tumors remained localized to the mucosal layer and six invaded the fibrous layer and the liver parenchyma. The invasion pattern of the six invasive cancers resembled that of the most common type of cholangiocarcinoma. Superficial spread of the cancer contiguous to the primary tumor was observed in four of the ten patients.

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Sakamoto, E., Nimura, Y., Hayakawa, N. et al. Clinicopathological studies of mucin-producing cholangiocarcinoma. J Hep Bil Pancr Surg 4, 157–162 (1997). https://doi.org/10.1007/BF02489781

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  • DOI: https://doi.org/10.1007/BF02489781

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