Abstract
Cholangiocarcinomas that produced clinically recognizable mucin (mucin-producing cholangiocarcinomas) were studied in ten patients. These ten represented 5.8% of all cholangiocarcinomas resected at our department. All tumors arose from the intrahepatic bile ducts. Macroscopically, the ten tumors were classified as: “ductectatic type” (n=3), in which papillary tumors developed in diffusely dilated intrahepatic bile ducts; “cystic type” (n=5), in which a large cystic tumor was present in the liver; and “intermediate type” (n=2), characterized by a large cystic lesion and a solid mass that infiltrated the liver parenchyma. Histologically, four tumors remained localized to the mucosal layer and six invaded the fibrous layer and the liver parenchyma. The invasion pattern of the six invasive cancers resembled that of the most common type of cholangiocarcinoma. Superficial spread of the cancer contiguous to the primary tumor was observed in four of the ten patients.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Nagino M, Nimura Y, Hayakawa N, Kamiya J, Shionoya S, Fukatsu T, Fukada S (1989) A clinicopathological study of mucus-producing bile duct carcinoma (in Japanese with English abstract). Nippon Geka Gakkai Zasshi (J Jpn Surg Soc) 92:695–704
Hasegawa H, Nimura Y, Hayakawa N, Kamiya J, Maeda S, Iyomasa Y (1983) A case report of biliary cystadenocarcinoma diagnosed preoperatively by percutaneous transhepatic cholangioscopy (PTCS) (in Japanese with English abstract). Nippon Shokakigeka Gakkai Zasshi (Jpn J Gastroenterol Surg) 16:1380–1383
Isogai M, Nimura Y, Hayakawa N, Hasegawa H, Asai M, Kamiya J, Maeda S, Okamoto S, Yamase H, Kishimoto H, Shionoya S (1986) A case of mucus-producing cholangiocarcinoma with superficial spread (in Japanese with English abstract). Nippon Shokakigeka Gakkai Zasshi (Jpn J Gastroenterol Surg) 19:710–713
Yamase H, Nimura Y, Hayakawa N, Hasegawa H, Maeda S, Kamiya J, Miyazaki Y, Okamoto S, Kishimoto H, Shionoya S (1987) A case of mucus producing cholangio carcinoma presented by jaundice by the mucus obstruction (in Japanese with English abstract). Nippon Shokakigeka Gakkai Zasshi (Jpn J Gastroenterol Surg) 20:879–882
Iwase M, Nimura Y, Hayakawa N, Hasegawa H, Kamiya J, Shionoya S (1988) A case of biliary cystadenocarcinoma originated in the right caudal lobe, diagnosed by percutaneous transhepatic cholangioscopy (PTCS) before operation (in Japanese with English abstract). Nippon Shokakigeka Gakkai Zasshi (Jpn J Gastroenterol Surg) 21:905–908
Bhuiya MMR, Nimura Y, Hayakawa N, Kamiya J, Kondo S, Iyomasa S, Shionoya S (1992) An unusual growth pattern of a mucin-producing intrahepatic cholangiocellular carcinoma involving the hepatic hilus. Hepato-Gastroenterology 39:66–69
Bhuiya MMR, Nimura Y, Kamiya J, Kondo S, Iyomasa S, Shionoya S, Nagino M, Hayakawa N (1993) Carcinoma of the hepatic hilus with superficial spreading to the intrahepatic segmental bile ducts: Report of a case. J Hep Bil Pancr Surg 1:22–26
Helpap B (1977) Malignant papillomatosis of the intrahepatic bile ducts. Acta Hepato-Gastroenterol 24:419–425
Yamasaki I, Tagata K, Hamamoto Y, Goto S (1976) An autopsy case of mucinous cystadenocarcimona of the liver. Yonago Act Med 20:142–146
Yamao K, Nakazawa S, Naito Y, Kimoto E, Morita K, Inui K, Ohnuma T, Funakawa T, Hayashi Y (1986) Clinicopathological study of mucus-producing pancreatic tumors (in Japanese with English abstract). Nippon Shokakibyo Gakkai Zasshi (Jpn J Gastroenterol) 83:2588–2597
Yamada M, Kozuka S, Yamao K, Nakazawa S, Naitoh Y, Tsukamoto Y (1991) Mucin-producing tumor of the pancreas. Cancer 68:159–168
Nimura Y (1993) Staging of biliary carcinoma: Cholangiography and cholangioscopy. Endoscopy 25:76–80
Nakazawa S, Naito Y, Ichikawa M, Kazikawa, M, Kimoto E (1978) Epithelial expansion of bile duct carcinoma (in Japanese with English abstract). Nippon Shokakibyo Gakkai Zasshi (Jpn J Gastroenterol) 75:1370–1376
Nimura Y (1990) Percutaneous transhepatic cholangioscopy. Gann Monograph on Cancer Res 37:67–73
Wheeler DA, Edmondson HA (1985) Cystadenoma with mesenchymal stroma (CMS) in the liver and bile ducts: A clinicopathologic study of 17 cases, 4 with malignant change. Cancer 56:1434–1445
Akwari OE, Tucker A, Seigler H, Itani KMF (1990) Hepatobiliary cystadenoma with mesenchymal stroma. Ann Surg 211:18–27
Devaney K, Goodman ZD, Ishak KG (1994) Hepatobiliary cystadenoma and cystadenocarcinoma: A light microscopic and immunohistochemical study of 70 patients. Am J Surg Pathol 18:1078–1091
Author information
Authors and Affiliations
About this article
Cite this article
Sakamoto, E., Nimura, Y., Hayakawa, N. et al. Clinicopathological studies of mucin-producing cholangiocarcinoma. J Hep Bil Pancr Surg 4, 157–162 (1997). https://doi.org/10.1007/BF02489781
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02489781