Abstract
In 117 patients with oral cancer who were examined scintigraphically and histopathologically, the tumor blood flow was estimated scintigraphically immediately after administration of99mTc-Hydroxymethylene-diphosphate (99mTc-HMDP). The radioactivity was measured in the venous phase (30 to 40 seconds after administration) and in the blood pool phase (1 to 3 minutes), and the radioactivity ratios of the tumor to the control region in both phases, (venous ratio, VR and blood pool ratio, BPR, respectively) were calculated. The early image with99mTc-HMDP (early image) was obtained 5 minutes after administration, and the image with67Ga-citrate (Ga-image) was obtained 3 days after administration. Among the tumor classified histopathologically as showing rich, intermediate and poor vascularity, those with poor vascularity showed small VR (M±SD=0.97±0.08) and BPR (1.02±0.04), whereas those with rich vascularity showed large VR (1.39±0.01) and BPR (1.31±0.16). Early image demonstrating tumor was frequent among tumors with large VR (78%) and with large BPR (100%). Of tumors under 3 cm in diameter, 65% showed intermediate or rich vascularity and positive early image for tumor blood flow. These results suggest that the detection of small soft tissue tumors can be improved by combining the early image with the Ga-image.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Swartzendruber, D.C., Nelson, B., and Hayes, R.L.: Gallium-67 Localization in Lysosomal-like Granules of Leukemic and Nonleukemic Murine Tissues.J Nat Cancer Inst 46: 941–952, 1971.
Osawa, T., Kanno, T., Nobesawa, S. and Fujii, C.: Tumor scintigraphy: comparison and clinical evaluation of67Ga-citrate and75Se-selenomethionine.Jpn J Nucl Med 16: 871–895, 1979 (in Japanese).
Demangeat, J.L., Constantinesco, A., Brunot, B., Foucher, G., and Farcot, J.M.: Three-Phase Bone Scanning in Reflex Sympathetic Dystrophy of the Hand.J Nucl Med 29: 26–32, 1988.
Otsuka, N., Fukunag, M., Furukawa, Y., and Tanaka, H.: The usefulness of early whole body scintigraphy in the detection of bone metastasis from prostatic cancer.J J Nucl Med 31: 541–550, 1994.
Folkman, J.: Tumor angiogenesis.Advances in Cancer Research 43: 175–203, 1985.
Gullino, P.M., and Grantham, P.H.: Studies on the exchange of fluides between host and tumor. II. The blood flow of hepatoma and other tumors in rats and mice.J Natl Cancer Inst 27: 1465–1491, 1961.
Kumano, M., Tamura, K., Hamada, T., Ishida, O., Kajita, A., Ushio, K., and Okuno, T.: Evaluation of bone diseases using dynamic bone scintigraphy.Nippon Act Radiol 43: 1393–1406, 1983 (in Japanese).
Rubin, P., and Casarett, G.: Microcirculation of tumors Part I: anatomy, function and necrosis.Clin Radiol 17: 220–229, 1966.
Larson, S.M.: Mechanism of localization of Gallium-67 in tumors.Seminar in Nucl Med 8: 193–203, 1978.
Tsan, M.-F., and Scheffel, U.: Mechanism of Gallium-67 accumulation in tumors.J Nucl Med 27: 1215–1219, 1986.
Anghileri, L.J., Crone-Escanye, M.-C., and Thouvenot, P.: Mechanism of Gallium-67 accumulation by tumors: Role of cell membrane permeability.J Nucl Med 29: 663–668, 1988.
Weiner, R.E., Schreiber, G.J., and Hoffer, P.B.: In vitro transfer of Ga-67 from transferrin to ferritin.J Nucl Med 24: 608–614, 1983.
Rogers, W., Edlich, R.F., Lewis, D.V., and Aust, J.B.: Tumor blood flow. I. Blood flow in transplantable tumors during growth.Surg Clin N America 47: 1473–1482, 1967.
Reinhold, H.S.: Improved microcirculation in irradiated tumor. Eur JCancer 7: 273–280, 1971.
Hara, H.: An electron microscopic study of tumor blood vessels in oral squamous carcinoma with special reference to the endotherium. J JpnOral Surg 33: 270–289, 1987 (in Japanese).
Papadimitrion, J.M., and Wood, A.E.: Structural and functional characteristics of the microcirculation in neoplasmas.J Pathol 116: 65–72, 1975.
Nitta, K., Ando, A., and Ando, I.: Mechanism of67Ga uptake by an experimental abscess-Permeability of plasma from blood vessel in abscess-.Radioisotope 34: 317–321, 1985 (in Japanese).
Sato, T., Suenaga, S., Morita, Y., and Noikura, T.: Evaluation of scintigraphy with 67-Ga citrate of oral malignant tumor.J Jpn Stomatol Soc 40: 961–962, 1991 (in Japanese).
Cataland, S., Cohen, C., and Sapirstein, L.A.: Relationship between size and perfusion rate of transplanted tumor.J Natl Cancer Inst 29: 389–394, 1962.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sato, T., Hayakawa, K., Miyahara, M. et al. Scintigraphic detection of oral cancer with early bone scintigraphic image. Oral Radiol. 13, 1–9 (1997). https://doi.org/10.1007/BF02489638
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02489638