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Assessment of hepatic function by blood ketone body ratio

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Journal of Hepato-Biliary-Pancreatic Surgery

Abstract

The arterial blood ketone body ratio is a non-invasive means of evaluating mitochondrial ATP synthesis and the related energy status of the liver, in which arterial blood is used, instead of the sampling of liver tissue or the isolation of mitochondria. We discuss AKBR in relation to: ATP synthesis, the rationale of using AKBR for assessment of the intramitochondrial redox state, factors affecting the intramitochondrial redox state, regulation of the speed of ATP synthesis by the oxidized/reduced form of pyridine nucleotid (NAD+/NADH) ratio, and the clinical applications of AKBR.

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Authors and Affiliations

  1. Department of Surgery, Kyoto City Hospital, 1-2-Higashi Takada-cho Mibu, 604, Nakagyo, Kyoto, Japan

    Akira Tanaka

  2. Department of Gastroenterological Surgery, Graduate School of Medicine, Kyoto University, 54 Kawara-cho, Shogoin, 606, Sakyo, Kyoto, Japan

    Yoshio Yamaoka

Authors
  1. Akira Tanaka
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  2. Yoshio Yamaoka
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Tanaka, A., Yamaoka, Y. Assessment of hepatic function by blood ketone body ratio. J Hep Bil Pancr Surg 4, 241–248 (1997). https://doi.org/10.1007/BF02489020

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  • DOI: https://doi.org/10.1007/BF02489020

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