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Transitional cell carcinoma of the ovary: Report of three cases

  • Toru Sugiyama
  • Takashi Nishida
  • Akio Kataoka
  • Kan Komai
  • Naofumi Ookura
  • Toshio Oobuchi
  • Michiaki Yakushiji
Original Article

Abstract

Background

We investigated retrospectively the records and tissue samples of patients with primary ovarian transitional cell carcinoma to determine clinical and pathologic features.

Methods

The records of 3 patients with ovarian transitional cell carcinoma were reviewed using data from several imaging techniques: transvaginal ultrasound, computed tomography, and magnetic resonance imaging. We also determined levels of several tumor marker molecules; and the level of carbohydrate antigen 125 (CA 125), was examined by means of immunohistochemistry.

Results

The tumors of 2 patients were classified as pure trnasitional cell carcinoma; in the remaining patient, as predominantly transitional cell carcinoma. All tumors were bilateral, and 2 of the 3 tumors formed solid masses. Areas of irregular high intensity signals were seen in magnetic resonance images of the solid parts of the tumors. All 3 tumors tested positive for CA 125; histochemical expression was confined to the tumor cell membrane and/or the cytoplasm in all cases. The tumors of all 3 patients tested negative for carcinoembryonic antigen (CEA), and second-look laparotomies did not reveal any residual neoplasms in any of the patients. The patients have been in a disease-free state for 34, 42, and 14 months, respectively.

Conclusion

Our results suggest that transitional cell carcinomas tend to arise bilaterally and to form solid tumors. Magnetic resonance imaging was a useful diagnostic modality in these cases. Transitional cell carcinoma was characterized by the presence of CA 125 and the absence of CEA.

Key words

ovary transitional cell carcinoma magnetic resonance imaging CA125, CEA 

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Copyright information

© JSCO/CLJ 1997

Authors and Affiliations

  • Toru Sugiyama
    • 1
  • Takashi Nishida
    • 1
  • Akio Kataoka
    • 1
  • Kan Komai
    • 1
  • Naofumi Ookura
    • 1
  • Toshio Oobuchi
    • 1
  • Michiaki Yakushiji
    • 1
  1. 1.Department of Obstetrics and GynecologyKurume University School of MedicineKurumeJapan

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