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Assessment of image quality of contrast-enhanced power doppler imaging in hepatocellular carcinoma with the personal ultrasound imager: Comparison with the conventional machine

Journal of Medical Ultrasonics volume 30, pages 31–38 (2003)Cite this article

Abstract

Objective

To evaluate the usefulness of contrast-enhanced power Doppler imaging with the personal ultrasound imager in depicting intratumoral vascularity in hepatocellular carcinoma.

Materials and Methods

Contrast-enhanced power Doppler imaging was used to examine 52 hepatocellular carcinoma nodules in 29 patients, using both the personal ultrasound imager and the conventional ultrasound machine in combination with intravenous injection of Levovist®. Results obtained using dynamic CT were used as the gold standard. The ability of the personal ultrasound imager to detect intratumoral vascularity was compared with that of the conventional ultrasound machine, and the usefulness of the personal ultrasound imager in assessing therapeutic effect after nonsurgical treatment was compared with that of dynamic CT at the same time.

Results

The personal ultrasound imager and the conventional ultrasound machine, using the fundamental power Doppler imaging mode (p=0.13) and contrast-enhanced power Doppler imaging mode (p=0.41), did not differ significantly in depicting the vascularity of the 52 hepatocellular carcinomas. The sensitivity, specificity, and accuracy of contrast-enhanced power Doppler imaging on the personal ultrasound imager were 95.5%, 87.5%, and 94.2%, respectively, in close agreement with results obtained using dynamic CT. After the 22 hepatocellular carcinomas were treated, the personal ultrasound imager provided diagnostic accuracy of 90.9% on residual tumors when compared with results obtained by dynamic CT, and results obtained using the conventional ultrasound machine were similar.

Conclusion

The highly portable personal ultrasound imager using Levovist®-enhanced power Doppler imaging can clearly depict the intratumoral vascularity of hepatocellular carcinoma nodules before and after treatment, achieving results very close to those obtained using the conventional diagnostic ultrasound machine. The personal ultrasound imager is an alternative to the conventional ultrasound machine for depicting tumor vascularity.

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References

  1. Tanaka S, Kitamura T, Fujita M, et al: Color Doppler flow imaging of liver tumors. AJR Am J Roentgenol 1990;154: 509–514.

    PubMed  CAS  Google Scholar 

  2. Takayasu K, Moriyama N, Muramatsu Y, et al: The diagnosis of small hepatocellular carcinomas: efficacy of various imaging procedures in 100 patients. AJR Am J Roentgenol 1990;155: 49–54.

    PubMed  CAS  Google Scholar 

  3. Kudo M: Imaging diagnosis of hepatocellular carcinoma and premalignant/borderline lesions. Semin Liver Dis 1999;19: 297–309.

    PubMed  CAS  Article  Google Scholar 

  4. Kudo M, Tomita S, Tochio H, et al: Sonography with intraarterial infusion of carbon dioxide microbubbles (sonographic angiography): value in differential diagnosis of hepatic tumors. AJR Am J Roentgenol 1992;158: 65–74.

    PubMed  CAS  Google Scholar 

  5. Matsui O, Kadoya M, Kameyama T, et al: Benign and malignant nodules in cirrhotic livers: distinction based on blood supply. Radiology 1991;178: 493–497.

    PubMed  CAS  Google Scholar 

  6. Kudo M: Morphological diagnosis of hepatocellular carcinoma: special emphasis on intranodular hemodynamic imaging. Hepatogastroenterology 1998;45: 1226–1231.

    PubMed  Google Scholar 

  7. Leen E, McArdle CS: Ultrasound contrast agent in liver imaging. Clin Radiol 1996;51 (suppl): 35–39.

    PubMed  Google Scholar 

  8. Kawasaki T, Itani T, Nakase H, et al: differential diagnosis between hepatocellula carcinoma and metastatic adnocarcinoma. J Gastroenterol Hepatol 1998;13: 1152–1160.

    PubMed  CAS  Google Scholar 

  9. Martinoli C, Derchi LE, Rizzatto G, et al: Power Doppler sonography: general principles, clinical applications, and future prospects. Eur Radiol 1998;8: 1224–1235.

    PubMed  CAS  Article  Google Scholar 

  10. Murphy KJ, Rubin JM: Power Doppler: it's a good thing: Semin Ultrasound CT MRI 1997;18: 13–21.

    CAS  Article  Google Scholar 

  11. Kim AY Choi BI, Kim TK, et al: Hepatocelluar carcinoma: power Doppler US with a contrast agent-preliminary results. Radiology 1998;209: 135–140.

    PubMed  CAS  Google Scholar 

  12. Bruce CJ, Spittell PC, Montgomery SC, et al: The personal ultrasound imager: abdominal aortic aneurysm screening. J Am Soc Echocardiogr 2000;13: 674–679

    PubMed  CAS  Article  Google Scholar 

  13. Pritchett AM, Bruce CJ, Bailey KR, et al: The personal ultrasound imager: extension of the cardiovascular physical examination. J Am Soc Echocardiogr 2000;13: 601M.

    Google Scholar 

  14. Rubin JM, Bude RO, Carson PL, et al: Power Doppler US: a potentially useful alternative to mean frequencybased color Doppler US. Radiology 1994;190: 853–856

    PubMed  CAS  Google Scholar 

  15. Choi BI, Kim TK, Han JK, et al: Power versus the conventional color Doppler sonography: comparison in the depiction of vasculature in liver tumors. Radiology 1996;200: 55–58.

    PubMed  CAS  Google Scholar 

  16. Lencioni R, Pinto F, Armillotta N, et al: Assessment of tumor vascularity in hepatocellular carcinoma: comparison of power Doppler US and color Doppler US. Radiology 1996;201: 353–358.

    PubMed  CAS  Google Scholar 

  17. Cosgrove D: Ultrasound contrast enhancement of tumors. Clin Radiol 1996;51 (suppl): 44–49.

    PubMed  Google Scholar 

  18. Maresca G, Summaria V, Colagrande C, et al: New prospects for ultrasound contrast agents. Eur J Radiol 1998;27: S171-S178.

    PubMed  Article  Google Scholar 

  19. Kim TK, Choi BI, Han JK, et al: Hepatic tumors: contrast agent-enhanced patterns with pulse-inversion harmonic US. Radiology 2000;216: 411–417.

    PubMed  CAS  Google Scholar 

  20. Ding H, Kudo M, Onda H, et al: Contrast-enhanced subtraction harmonic sonography for evaluating treatment response in patients with hepatocellular carcinoma. AJR Am J Roentgenol 2001;176: 661–666.

    PubMed  CAS  Google Scholar 

  21. Ding H, Kudo M, Onda H, et al: Evaluation of posttreatment response for hepatocellular carcinoma with phase-inversion harmonic US with coded pulse: comparison with dynamic CT. Radiology 2001;221: 721–730.

    PubMed  CAS  Google Scholar 

  22. Choi D, Lim HK, Kim SH, et al: Hepatocellular carcinoma treated with percutaneous radio-frequency ablation: usefulness of power Doppler US with a microbubble contrast agent in evaluating therapeutic response-preliminary results. Radiology 2000;217: 558–563.

    PubMed  CAS  Google Scholar 

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Affiliations

  1. Department of Gastroenterology and Hepatology, Kinki University School of Medicine, 377-2, Ohno-higashi, 589-8511, Osaka-Sayama, Osaka, Japan

    Yan Ling Wen, Masatoshi Kudo SJSUM, Yasunori Minami, Hobyung Chung, Yoichiro Suetomi, Hirokazu Onda, Masayuki Kitano & Toshihiko Kawasaki SJSUM

  2. Abdominal Ultrasound Unit, Kinki University School of Medicine, 377-2, Ohno-higashi, 589-8511, Osaka-Sayama, Osaka, Japan

    Kiyoshi Maekawa

  3. Department of Ultrasound, Sun Yat-Sen University of Medical Science Memorial Hospital, 107 Yanjianxi Road, 510120, Guangzhou, China

    Yan Ling Wen

Authors
  1. Yan Ling Wen
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  2. Masatoshi Kudo SJSUM
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  3. Yasunori Minami
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  4. Hobyung Chung
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  5. Yoichiro Suetomi
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  6. Hirokazu Onda
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  7. Masayuki Kitano
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  8. Toshihiko Kawasaki SJSUM
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  9. Kiyoshi Maekawa
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Wen, Y.L., Kudo, M., Minami, Y. et al. Assessment of image quality of contrast-enhanced power doppler imaging in hepatocellular carcinoma with the personal ultrasound imager: Comparison with the conventional machine. J Med Ultrasonics 30, 31–38 (2003). https://doi.org/10.1007/BF02485167

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  • DOI: https://doi.org/10.1007/BF02485167

Keywords

  • contrast medium
  • hepatocellular carcinoma
  • power Doppler imaging
  • ultrasound