European Archives of Oto-Rhino-Laryngology

, Volume 252, Supplement 1, pp S50–S58 | Cite as

Implicating adhesion molecules in nasal allergic inflammation

  • F. M. Baroody
  • B. -J. Lee
  • M. C. Lim
  • B. S. Bochner
Review Article

Abstract

Allergic rhinitis is now considered an inflammatory disorder where many leukocyte types, including eosinophils and T-lymphocytes, accumulate in increased numbers. Along with mast cells and other cells, they release a wide variety of mediators, cytokines, and granule constituents that can directly cause inflammation or activate the local vascular endothelium to futher enhance the recruitment of leukocytes through the expression and function of adhesion molecules. While the understanding of the importance of leukocyte and endothelial adhesion molecules is still at a very early stage, recent evidence has already begun to implicate these cell surface molecules in the pathogenesis of allergic diseases such as rhinitis and asthma. Additional studies, including the use of adhesion molecule antagonists when available, will clarify the importance of these structures in the pathophysiology of these disorders.

Key words

Allergic rhinitis Pathophysiology Adhesion molecules Eosinophils Mast cells 

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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • F. M. Baroody
    • 1
    • 3
  • B. -J. Lee
    • 1
    • 3
  • M. C. Lim
    • 1
    • 3
  • B. S. Bochner
    • 2
    • 3
  1. 1.Department of Otolaryngology - Head and Neck SurgeryThe Johns Hopkins School of MedicineBalitmoreUSA
  2. 2.Department of Medicine, Division of Clinical ImmunologyThe Johns Hopkins University School of MedicineBaltimoreUSA
  3. 3.Johns Hopkins Asthma and Allergy CenterClinical Immunology Unit Office 3BaltimoreUSA

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