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Standardized AgNOR analysis: its usefulness in surgical oncology

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Abstract

Recent improvements both in the staining quality and computer-aided quantitation of silver-stained nucleolar organizer region (AgNOR)-associated proteins offer the possibility to reliably investigate these proteins on routinely processed archival material. This article deals with the historical background, the recent introduction of a standardized quantitation, the clinical relevance, and future perspective for AgNOR evaluation. It is specifically emphasized that AgNOR analysis after both standardized staining and computer-aided quantitation (as recommended by the Committee on AgNOR Quantitation of the European Society of Pathology) is now regarded as the gold standard whenever routinely formalin-fixed and paraffin-embedded material is investigated.

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Authors and Affiliations

  1. Department of Surgery I, University of Innsbruck, Innsbruck, Austria

    D. Öfner

  2. Department of Pathology, University of Münster/Westfalia, Domagkstrasse 17, D-48149, Münster, Germany

    K. W. Schmid

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  1. D. Öfner
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  2. K. W. Schmid
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Öfner, D., Schmid, K.W. Standardized AgNOR analysis: its usefulness in surgical oncology. Histochem Cell Biol 106, 193–196 (1996). https://doi.org/10.1007/BF02484400

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