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Brain Tumor Pathology

, Volume 17, Issue 3, pp 159–163 | Cite as

High-grade adenoid cystic carcinoma originating from the lacrimal gland

  • Mizuhiko Terasaki
  • Takashi Tokutomi
  • Hikaru Maruiwa
  • Yasuo Sugita
  • Hiroshi Harada
  • Minoru Shigemori
Case Report

Abstract

Among primary lacrimal gland tumors, adenoid cystic carcinoma (ACC) is the most common malignant epithelial neoplasm; it is characterized by local intracranial invasion. A case with unusual dumbbell-type intracranial extension representing cavernous sinus syndrome is described. A 49-year-old woman was admitted to our hospital with right cavernous sinus syndrome. Computerized tomographic (CT) scans and magnetic resonance (MR) imaging demonstrated well-enhanced intraorbital and middle fossa tumors mimicking multifocal mass lesions. Operative findings revealed an ACC originating from the lacrimal gland and extending into the right cavernous sinus and middle fossa along the nerve sheath in the superior orbital fissure. Although MR image findings of intracranial ACC often resemble the image findings for meningiomas, intracranial ACC is very aggressive in comparison with meningioma. It is best treated surgically and aggressively.

Key words

Adenoid cystic carcinoma Cavernous sinus syndrome Lacrimal gland 

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References

  1. 1.
    Font RL, Gamel JW (1980) Adenoid cystic carcinoma of the lacrimal gland: a clinicopathologic study of 79 cases. In: Nicholson DH (ed) Ocular pathology update. Masson, New York, pp 277–283Google Scholar
  2. 2.
    Nasu M, Haisa T, Kondo T, et al (1998) Primary ductal carcinoma of the lacrimal gland. Pathol Int 48:981–984PubMedCrossRefGoogle Scholar
  3. 3.
    Alleyne CH Jr, Bakay RAE, Costigan D, et al (1966) Intracranial adenoid cystic carcinoma: case report and review of the literature. Surg Neurol 45:265–271CrossRefGoogle Scholar
  4. 4.
    Buchholz TA, Shimotakahara SG, Weymuller EA Jr, et al (1993) Neutron radiotherapy for adenoid cystic carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg 119:747–752PubMedGoogle Scholar
  5. 5.
    Shotton JC, Schmid S, Fisch U (1991) The infratemporal fossa approach for adenoid cystic carcinoma of the skull base and nasopharynx. Otolaryngol Clin North Am 24:1445–1464PubMedGoogle Scholar
  6. 6.
    González C, Zülch KJ (1964) Über die zylindromatösen Epithelioma der Schädelbasis (Zylindrome). Zentralbl Neurochir 25:111–125PubMedGoogle Scholar
  7. 7.
    Parzin KH, Gullane P, Clairmont AC (1978) Adenoid cystic carcinoma arising in salivary glands: a correlation of histological features and clinical course. Cancer 42:265–282CrossRefGoogle Scholar
  8. 8.
    Matsuba HM, Spector GJ, Thawley SE, et al (1986) Adenoid cystic salivary gland carcinoma: a histopathologic review of treatment failure patterns. Cancer 57:519–524PubMedCrossRefGoogle Scholar
  9. 9.
    Tellado MV, McLean IW, Specht CS, et al (1997) Adenoid cystic carcinoma of the lacrimal gland in childhood and adolescence. Ophthalmology 104:1622–1625PubMedGoogle Scholar
  10. 10.
    Banks ER, Frierson HF Jr, Mills SE, et al (1992) Basaloid squamous cell carcinoma of the head and neck: a clinicopathologic and immunohistochemical study of 40 cases. Am J Surg Pathol 16:939–946PubMedGoogle Scholar
  11. 11.
    Gormley WB, Sekhar LN, Wright DC, et al (1996) Management and long-term outcome of adenoid cystic carcinoma with intracranial extension: a neurosurgical perspective. Neurosurgery 38:1105–1113PubMedCrossRefGoogle Scholar
  12. 12.
    Morioka T, Matsushima T, Ikezaki K, et al (1993) Intracranial adenoid cystic carcinoma mimicking meningioma: report of two cases. Neuroradiology 35:462–465PubMedCrossRefGoogle Scholar
  13. 13.
    Conley J, Dingman DL (1974) Adenoid cystic carcinoma in the head and neck (cylindroma). Arch Otolaryngol 100:81–90PubMedGoogle Scholar
  14. 14.
    Spiro RH, Armstrong J, Harrison L, et al (1989) Carcinoma of major salivary glands: recent trends. Arch Otolaryngol Head Neck Surg 115:316–321PubMedGoogle Scholar
  15. 15.
    Vincentelli F, Grisori F, Leclercq TA, et al (1986) Cylindroma of the skull base. J Neurosurg 65:856–859PubMedCrossRefGoogle Scholar
  16. 16.
    Wakisaka S, Nonaka A, Morita Y, et al (1990) Adenoid cystic carcinoma with intracranial extension. Neurosurgery 26:1060–1065PubMedCrossRefGoogle Scholar
  17. 17.
    Witt RL (1991) Adenoid cystic carcinoma of the minor salivary glands. Ear Nose Throat J 70:218–222PubMedGoogle Scholar
  18. 18.
    Koka VN, Tiwari RM, Van der Waal I, et al (1989) Adenoid cystic carcinoma of the salivary glands: clinicopathological survey of 51 patients. J Laryngol Otol 103:675–679PubMedGoogle Scholar
  19. 19.
    Meldrum ML, Tse DT, Benedetto P (1998) Neoadjuvant intracarotid chemotherapy for treatment of advanced adenoid cystic carcinoma of the lacrimal gland. Arch Ophthalmol 116:315–321PubMedGoogle Scholar

Copyright information

© The Japan Society of Brain Tumor Pathology 2000

Authors and Affiliations

  • Mizuhiko Terasaki
    • 1
  • Takashi Tokutomi
    • 1
  • Hikaru Maruiwa
    • 1
  • Yasuo Sugita
    • 2
  • Hiroshi Harada
    • 2
  • Minoru Shigemori
    • 1
  1. 1.Department of NeurosurgeryKurume University School of MedicineKurumeJapan
  2. 2.Department of PathologyKurume University School of MedicineFukuokaJapan

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