Abstract
The preoperative levels of serum-soluble receptor for interleukin-2 (IL-2R) were determined by an enzyme-linked immunosorbent assay in 38 patients undergoing surgery for colorectal cancer and 98 healthy controls. The levels of serum-soluble IL-2R in the patients with colorectal cancer were significantly higher than those in the normal controls (P<0.05). Markedly elevated levels of serum-soluble IL-2R were recognized in patients with stage IV cancer, those with Dukes' stage D cancer, and those with liver metastasis. Moreover, the prognosis of patients with low levels of IL-2R (<531 U/ml) was significantly better than that of those with high levels (P<0.05). These findings demonstrate that an elevated concentration of soluble IL-2R might be a useful indicator of liver metastasis and poor prognosis in patients with colorectal carcinoma.
References
Mills GB (1993) Transmembrane signaling through hematopoietin receptors: interleukin 2 and erythropoietin. Semin Immunol 5:297–298
Mills GB, Schmandt R, Gibson S, Leung B, Hill M, May C, Shi YF, Branch DR, Radvanyi L, Truitt KE, Imboden J (1993) Transmembrane signalling by the interleukin 2 receptor: progress and conundrums. Semin Immunol 5:345–364
Mills GB (1993) Functional and molecular aspects of T cell activation. In: Cooper EL, Nisbet-Brown E (eds) Developmental immunology. Oxford University Press, Oxford, pp 333–364
Rubin LA, Nelson DL (1990) The soluble interleukin 2 receptor: biology, function and clinical application. Ann Intern Med 113:619–645
Rubin LA, Kurman CC, Fritz ME, Biddison WE, Boutin B, Yarchoan R, Nelson DL (1985) Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro. J Immunol 135:3172–3177
Pavlidis NS, Manoussakis MN, Germanidis GS, Moutsopoulos HM (1992) Serum-soluble interleukin-2 receptors in B-cell lymphoproliferative malignancies. Med Pediatr Oncol 20:26–31
Poulakis N, Sarandakou A, Rizos D, Phocas I, Kontozoglou TH, Polyzogopoulos D (1991) Soluble interleukin 2 receptors and other markers in primary lung cancer. Cancer 38:1045–1051
Owens OJ, Taggart C, Walker JJ, McKillop JH, Kennedy JH (1993) Interleukin-2 receptor and ovarian cancer. Br J Cancer 68:364–367
Murakami S, Satomi A, Ishida K, Murai H, Matsuki M, Hashimoto T (1994) Serum-soluble interleukin-2 receptor concentrations in patients with gastric cancer. Cancer 74:2745–2748
Murakami S, Hirayama R, Satomi A, Okubo K, Matsuki M, Sakata H, Tsuji Y (1997) Serum soluble interleukin-2 receptor levels in patients with breast cancer. Breast Cancer 4:25–28
Japanese Society for Cancer of the Colon and Rectum (1994) General rules for clinical and pathological studies on cancer of the colon, rectum and anus, 5th edn. Kanehara, Tokyo
Murakami S, Satomi A, Ishida K, Murai H, Okamura Y (1994) Serum-soluble interleukin-2 receptors in colorectal cancer. Acta Oncol 33:19–21
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Saito, H., Tsujitani, S., Katano, K. et al. Levels of serum-soluble receptor for interleukin-2 in patients with colorectal cancer. Surg Today 28, 1115–1117 (1998). https://doi.org/10.1007/BF02483977
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DOI: https://doi.org/10.1007/BF02483977