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Nesidioblastosis with hyperinsulinemic hypoglycemia in adults: Report of two cases

Surgery Today volume 29, pages 361–363 (1999)Cite this article

Abstract

We report herein the cases of two women, aged 34 years and 39 years, respectively, found to have hyperin-sulinemic hypoglycemia after presenting with a history of episodes of temporary loss of consciousness, nausea, and fainting. Under the suspected diagnosis of insulinoma, localization procedures were carried out, but no tumor was found. In both patients, a definite gradient in insulin concentration was found in the pancreas by percutaneous transhepatic or intraoperative portal venous sampling, and a misdiagnosis of insulinoma of the pancreatic body was made. During exploratory laparotomy no tumor was palpable in the pancreas, and intraoperative ultrasonography showed no low echoic mass in the pancreas. A distal pancreatectomy was performed in both patients, and histopathological examination of the resected specimens revealed graded slight hyperplasia of the islet cells.

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Authors and Affiliations

  1. Department of Surgery, Kurume University School of Medicine, 67 Asahimachi, 830-0011, Kurume, Japan

    Neofumi Eriguchi, Shigeaki Aoyagi, Masao Hara, Eiji Tanaka & Mitsuo Hashimoto

  2. First Department of Pathology, Kurume University School of Medicine, 67 Asahimachi, 830-0011, Kurume, Japan

    Atsuo Jimi

Authors
  1. Neofumi Eriguchi
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  2. Shigeaki Aoyagi
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  3. Masao Hara
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  4. Eiji Tanaka
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  5. Mitsuo Hashimoto
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  6. Atsuo Jimi
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Eriguchi, N., Aoyagi, S., Hara, M. et al. Nesidioblastosis with hyperinsulinemic hypoglycemia in adults: Report of two cases. Surg Today 29, 361–363 (1999). https://doi.org/10.1007/BF02483064

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  • DOI: https://doi.org/10.1007/BF02483064

Key Words

  • nesidioblastosis
  • hyperinsulinemia
  • hypoglycemia