Abstract
To investigate the relationship between the concentration of interleukin-1α (IL-1α) and liver metastasis in gastric cancer, the concentration of IL-1α was measured in homogenized tumor samples from 61 patients with gastric cancer. A significantly higher concentration of IL-1α was observed in tumors from patients with liver metastasis than in those from patients without liver metastasis; in differentiated type tumors than in undifferentiated type tumors; in tumors associated with moderate to severe venous invasion than in those associated with mild or no invasion; and in tumors with expansive or intermediate growth pattern (INFα, INFβ) than in those with an infiltrative pattern (IFNγ) by Student’st-test. Stepwise logistic regression revealed IL-1α, depth of invasion, venous invasion, and tumor size to be associated independently with liver metastasis. These findings led us to conclude that the IL-1α concentration was on eof the most useful determinants of liver metastasis among the various clinicopathologic characteristics.
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References
Strinimas U, Pahlsson P, Lundbland A (1996) E-selectin: Sialyl Lewis, a dependent adhesion of colon cancer cells, is inhibited differently by antibodies against E-selectin ligands. Scand J Immunol 44:197–203
Mackay AR, Ballin M, Pelina MD, Farina AR, Nason AM, Hartzler JL (1992) Effect of phorbol ester and cytokines on matrix metalloproteinase and tissue inhibitor of metalloproteinase expression in tumor and normal cell lines. Invas Metastas 12:168–184
Sato H, Seiki M (1993) Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells. Oncogene 8:395–405
Shima J, Sasaguri Y, Kusukawa J, Nakano R, Yamana H, Fujita H (1993) Production of matrix metalloproteinase 9 (92-kDa gelatinase) by human oesophageal squamous cell carcinoma in response to epidermal growth factor. Br J Cancer 67:721–727
Lengyel E, Klostergaard J, Boyd D (1995) Stimulation of urokinase expression by TNF-alpha requires the activation of binding sites for the AP-1 and PEA3 transcription factors. Biochim Biophys Acta 1268:65–72
Japanese Research Society for Gastric Cancer (1993) The General Rules for Gastric Cancer Study, 12th edn. Kanehara, Tokyo
Kabir S, Daar GA (1995) Serum level of interleukin-1, interleukin-6 and tumor necrosis factor-alpha in patients with gastric carcinoma. Cancer Lett 95:207–212
Dinarello C (1991) Interleukin-1 and interleukin-1 antagonism. Blood 77:1627–1652
Ito R, Kitadai Y, Kyo E (1993) Interleukin-1α acts an autocrine growth stimulator for human gastric cells. Cancer Res 53:4102–4106
Im S-Y, Ko H-M, Ko Y-S (1996) Augmentation of tumor metastatsis by platelet-activating factor. Cancer Res 56:2662–2665
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Furuya, Y., Ichikura, T. & Mochizuki, H. Interleukin-1α concentration in tumors as a risk factor for liver metastasis in gastric cancer. Surg Today 29, 288–289 (1999). https://doi.org/10.1007/BF02483025
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DOI: https://doi.org/10.1007/BF02483025